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Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower-extremity varicose veins  Enrico Ascher, MD, Theresa Jacob,

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Presentation on theme: "Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower-extremity varicose veins  Enrico Ascher, MD, Theresa Jacob,"— Presentation transcript:

1 Expression of molecular mediators of apoptosis and their role in the pathogenesis of lower-extremity varicose veins  Enrico Ascher, MD, Theresa Jacob, PhD, Anil Hingorani, MD, Boris Tsemekhin, MD, Yilmaz Gunduz, MD  Journal of Vascular Surgery  Volume 33, Issue 5, Pages (May 2001) DOI: /mva Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

2 Fig. 1 Representative photomicrographs of immunohistochemical analysis for expression of apoptosis-related molecules. Formalin-fixed paraffin-embedded tissues were processed for localization of bax and PARP, as described in the methods section. Brown staining (peroxidase) indicates immunopositivity. A, Negative control; venous tissue sections were processed for immunohistochemistry with omission of primary antibodies (original magnification, 200×). B, Varicose vein section demonstrating expression of bax in smooth muscle cells (original magnification, 400×). C, Control vein tissue stained with antibody for bax. Note transmural expression of bax in venous wall (original magnification, 100×). D, Healthy vein section illustrating the expression of bax in the vasa vasorum of adventitial layer (original magnification, 400×). E, Varicose vein tissue demonstrating immunoreactivity to PARP in media (original magnification, 400×). F, Vasa vasorum of healthy vein tissue showing expression of PARP (original magnification, 400×). G, Positive control for PARP expression (tumor tissue; original magnification, 100×). H, Positive control for bax expression (tumor tissue; original magnification, 400×). Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

3 Fig. 2 Graph demonstrating number of cells per high-power field that stain positive for bax in venous wall layers of control and varicose veins. All values are expressed as mean ± SEM. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

4 Fig. 3 Number of cells per high-power field that are immunoreactive to PARP antibody in intima, media, and adventitia of healthy veins and varicose veins. All values are expressed as mean ± SEM. Journal of Vascular Surgery  , DOI: ( /mva ) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

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