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Presentation on theme: "Lab and pilot plant tours Scaling up www.abpischools.org.uk."— Presentation transcript:

1 Lab and pilot plant tours Scaling up

2

3 Pear shaped flask Bunsen burner Reflux condenser Vacuum filtration Preparation of Aspirin (typical A level procedure)

4 1. Weigh out 2g of 2-hydroxybenzoic acid and place it in a pear shaped flask. (The starting material is a fluffy irritant white solid.) 2. Add 4.0cm 3 of ethanoic anhydride. (A colourless liquid with a pungent smell.) 3. The reaction mixture will get slightly warm so cool it by swirling the flask under running water. 4. When it is cool, add two anti-bumping granules. 5. Heat under reflux for 30 minutes. 6. Cool the mixture. 7. Pour into 100cm 3 of cold water containing 10cm 3 of dilute sulphuric acid. Stir and allow the resulting suspension to stand for 15 minutes. 8. Filter off the crystals that form. Dry and weigh the product. Preparation of Aspirin (typical A level procedure)

5 The chemistry used to make aspirin 2-hydroxybenzoic acid ethanoic anhydride aspirin

6 1. Weigh out 2g of 2-hydroxybenzoic acid and place it in a pear shaped flask. (The starting material is a fluffy irritant white solid.) How would you do this for 20kg - 10,000 times the scale? Preparation of Aspirin (typical A level procedure)

7 1. Weigh out 2g [20kg] of 2-hydroxybenzoic acid and place it in a pear shaped flask. (The starting material is an irritant fluffy white solid.) Preparation of Aspirin (typical A level procedure)

8 2. Add 4.0cm 3 [40 litres] of ethanoic anhydride. (A colourless liquid with a pungent smell). Temperature probe Preparation of Aspirin (typical A level procedure)

9 2. Add 4.0cm 3 [40 litres] of ethanoic anhydride. (A colourless liquid with a pungent smell). Preparation of Aspirin (typical A level procedure)

10 3. The reaction mixture will get slightly warm so cool it by swirling the flask under running water. Preparation of Aspirin (typical A level procedure)

11 3. The reaction mixture will get slightly warm so cool it by swirling the flask under running water. Preparation of Aspirin (typical A level procedure)

12 3. The reaction mixture will get slightly warm so cool it by swirling the flask under running water. Preparation of Aspirin (typical A level procedure)

13 4. When it is cool, add two anti-bumping granules. 5. Heat under reflux for 30 minutes. Preparation of Aspirin (typical A level procedure)

14 Heat under reflux for 30 minutes °C Time in minutes

15 5. Heat under reflux for 30 minutes. Condenser The maximum transfer of heat from the fluid in the jacket to the reaction mixture is 2° per minute Preparation of Aspirin (typical A level procedure)

16 Heat under reflux for 30 minutes °C Time in minutes

17 6. Cool the mixture. 7. Pour into 100cm 3 [1000 litres] of cold water containing 10cm 3 [100 litres] of dilute sulphuric acid. Stir and allow the resulting suspension to stand for 15 minutes. Condenser 8. Filter off the crystals that form. Dry and weigh the product. Preparation of Aspirin (typical A level procedure)

18 8. Filter off the crystals that form. Dry and weigh the product. Preparation of Aspirin (typical A level procedure)

19 Filter off the crystals that form

20 Dry and weigh the product

21


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