1. From: Visual Field Progression in Glaucoma: Estimating the Overall Significance of Deterioration with Permutation Analyses of Pointwise Linear Regression (PoPLR)
Invest. Ophthalmol. Vis. Sci ;53(11): doi: /iovs
Figure Legend:
Case 1. (A) Grayscale maps of sensitivity of the first, middle, and last examinations, with patient age at each examination. (B) Mean deviation over time with fitted simple linear regression line, with slope and associated P value (two-sided). A red line indicates a significantly negative (P < 0.05) slope. The three examinations in A are indicated by black dots. (C) A map of slopes and associated P values (one-sided) of total deviation over time. Colors indicate the direction of the slope (red: slope 0 dB/year). Gray squares highlight locations with P < 0.05, which contribute to the Truncated Product Method test-statistic (S) used in PoPLR. To show which locations would be classified as changing by PLR criteria, locations outlined with a dark square indicate a two-sided P value < In addition, slopes below a critical value of −1 dB/year are further indicated by a heavily outlined square. Locations with sensitivities ≤0 dB across the entire series are represented by a gray point (slope and P value not available). (D) The permutation distribution SP of the calculated test statistics S for 5000 unique, random permutations. Values of S > 70 are binned together. The test statistic for the observed series S obs is indicated by the position of the red line—the further to the right, the more significant the change in the observed series. An overall significance for deterioration, P associated with S obs, is also shown. The 95th percentile (S 95) of the distribution, indicated by a black dashed arrow, is the cutoff beyond which S obs would be considered significant (P < 0.05).
Date of download: 10/15/2017
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