1. Moderator : Dr. C.V.R.Mohan

2. The common carotids bifurcate into: - External carotid artery - Internal carotid artery Carotid circulation supplies 80 to 90% of cerebral blood supply Vertebral circulation supplies 10 to 20% of cerebral blood supply Continued blood supply to the brain will depend entirely on adequate collateral blood flow through the circle of Willis if no shunt is used during CEA. Bilateral carotid disease have a higher risk of perioperative stroke after CEA than patients with unilateral disease only

3. Hypoglossal nerve Vagus Nerve Recurrent Laryngeal Nerve Mandibular Branch of Facial Nerve Important to document preoperative neurologic examination

4. Atherosclerotic plaque tends to develop at the bifurcation of ICA and ECA Problem of embolization > occlusion or insufficiency

5. Clinical presentation: Varies by site of stenosis and distal embolization Isolated cervical Bruit in asymptomatic pts - high risk of stroke Part of a generalized vascular disease Amaurosis Fugax ( Transient Mono ocular blindness ) - ophthalmic artery Transient Ischemic Event (TIA) - Sudden onset of focal neurologic deficit which resolves within 24 hours Reversible Ischemic Neurologic Deficit (RIND) Neurologic dysfunction greater than 24 hours but less than 2 weeks Important to differentiate between carotid disease and posterior vertebro-basilar artery disease

6. Advanced age Hypertension Diabetes Hyperlipidemia Hypercoagulable states Smoking

7. Most common Non invasive test - carotid duplex ultrasonography Positive tests are followed by confirmatory angiography Treatment options : Medical management Carotid endarterectomy Percutaneous transluminal Carotid angioplasty & stenting Indications for surgery : TIAs with angiographic evidence of stenosis RIND with >70% stenosis or ulcerated plaque with or without stenosis An unstable neurological status that persists despite anticoagulation

8. Individualized - assessment of stroke risk weighing medical management versus risk of perioperative stroke, death, or cardiac event Large multicenter trials - comparing medical versus surgical management ( anti-platelet therapy versus surgery ) Patients with a minimum of 50% to 70% stenosis are candidates with ipsilateral disease and acceptable surgical risk The greater the degree of stenosis, the greater the difference in outcome statistics compared to medical therapy.

9. Prophylactic intervention to prevent cerebral infarction and relieve symptoms of carotid atherosclerosis. This involves occluding the common,external, and internal carotid arteries, isolating the diseased segment, opening the vessel wall, and removing the plaque. The vessel is then closed. If the remaining intima is too thin, the vessel is closed with a vein graft or a synthetic (Dacron) patch.

11. Use of a shunt during the period of carotid cross clamping depends on whether evidence of cerebral ischemia becomes apparent with cross clamping of the carotid artery. AdvantagesDisadvantages Allows hemispheric cerebral blood flow (CBF) to be maintained during cross clamping. Especially advantageous when the endarterectomy is expected to be complex and require a long period of time. Technical problems - plaque or air embolism, kinking of the shunt, shunt occlusion on the side of the vessel wall, and injury to the distal internal carotid artery, does not guarantee adequate CBF nor prevent thromboembolic stroke, impairs surgical access & ↑ cross clamping time

12. Advantages Avoidance of surgical incision, Minimal anesthetic requirements, Avoidance of cranial nerve injury and wound infections, Shorter duration of induced carotid occlusion by the balloon catheter than with surgical clamping of the carotid artery Lower hospital costs for shorter hospital and intensive care unit (ICU) stays. Clinical trials comparing CEA with angioplasty have been done. Study results - angioplasty & carotid endarterectomy equally effective in preventing stroke. Also disabling stroke & death rates were same after surgery & stenting

13. Other manifestations of generalized arteriosclerosis - Coronary artery disease, Hypertension, and Renal disease  renal dysfunction (end - organ effects) Medical conditions associated with Obesity, Diabetes mellitus, and Pulmonary disease secondary to cigarette smoking The patient's Neurologic Status and airway will need to be evaluated.

14. 30% to 50% of patients undergoing carotid endarterectomy (CEA) have coronary artery disease. Patients should be specifically asked whether they have angina, or have had a myocardial infarction (MI) or congestive heart failure. Based on the Cardiac Risk Stratification for noncardiac surgical procedures by the AHA/American College of Cardiology Task force on assessment of therapeutic cardiovascular procedures, CEA is classified as an Intermediate Risk procedure with a reported cardiac risk generally less than 5%.

15. Hypertension is present in 55% to 80% of patients with carotid artery disease, and its presence would alter intraoperative blood pressure management. A range of acceptable blood pressures, where the patient is free of symptoms of both cardiac and cerebral ischemia should be determined To provide acceptable range of perfusion pressures during anaesthesia & surgery. Normal autoregulation will be lost in blood vessels in the ishcemic region Raising the blood pressure excessively to improve cerebral perfusion may exacerbate myocardial ischemia Lowering the blood pressure to reduce the work of the heart may compromise cerebral perfusion, exacerbating cerebral ischemia.

16. Aspirin should be continued throughout the perioperative period Continuing of other agents must be balanced against the risk of bleeding Clopidogrel - stopped 1-5 days before surgery depending on presence, type & type of coronary stenting. Preferable to medically optimize the patient with Uncontrolled Hypertension Or Untreated Metabolic Disease, or if possible, delay surgery in the patient with a recent MI Presence of crescendo transient ischemia attacks (TIAs) may not allow the delay. AIRWAY ASSESMENT For ease of ventilation and intubation. If it is difficult to establish ventilation pt. may become hypercarbic during induction  adverse effects on regional cerebral blood flow (CBF). Range of motion of the patient's neck that is tolerated - Extreme extension and rotation of the neck may occlude the patient's vertebral artery and contribute to postop neurologic deficits.

17. # Management of intraoperative ventilation should be aimed at maintaining the patient's normal arterial carbon dioxide level. One of the anesthetic goals for CEA under GA is to have a patient who promptly emerges from anesthesia and is able to cooperate with a basic neurologic evaluation. Reassuring preoperative visit Benzodiazepine (e.g., diazepam 5 mg orally, 1 hour preoperatively or midazolam 1 to 2 mg intravenously) will provide anxiolysis and minimal respiratory depression

18. Protecting brain and heart from ischemic injury Maintaining hemodynamic stability Ablate stimulatory(pain) and stress response to surgery Awake, cooperative patient at end of procedure allowing clear neurologic evaluation

19. Electrocardiogram (ECG) leads II and V5 Noninvasive blood pressure monitor Pulse oximetry End-tidal capnometry Esophageal temperature An intraarterial catheter should be used to monitor the patient's blood pressure closely. CEA is not an operation in which large fluid shifts are anticipated. A pulmonary artery catheter/CVP/TEE should not be required in the patient with normal left ventricular function i.v access - one well-secured and well-running, medium-bore, intravenous catheter because major blood loss or fluid shifts during CEA are rare

20. Adequate cerebral perfusion Helps to decide when to place the shunt during carotid cross clamping No monitoring modality is as effective as watching an awake patient If the patient receives general anesthesia : Electroencephalograph (EEG) - often used, Somatosensory Evoked Potentials (SSEP), Transcranial Doppler, Internal Carotid Stump Pressure, And Jugular Venous Oxygen Saturation Cerebral Oximetry Direct Xenon Cerebral Blood Flow Measurement

21. Intraoperative EEG monitoring is the most common choice for CEA Continuous, non-invasive, inexpensive and provides direct feedback within seconds after carotid clamping that the brain is adequately perfused and oxygenated. Increasing levels of ischemia lead to a decrease in recorded electrical activity Its sensitivity in detecting perioperative stroke is limited - most strokes occur following surgery and are likely related to thromboembolic phenomena. Rapid changes in anesthetic depth may also complicate interpretation. This is particularly relevant where barbiturates or propofol infusions are used to induce EEG suppression in hopes of reducing CMRO 2

22. Deep brain structures are not monitored by EEG. In patients with preexisting or fluctuating neurologic deficits - false negative. EEG may not be an ischemia-specific monitor - changes that occur with hypothermia, hypocarbia, hypoxemia, and deep anesthesia mimic electroencephalographic signs of ischemia # EEG changes secondary to anesthetics or hypothermia are more likely to be bilateral, whereas hemispheric ischemia is more likely to affect the electrical activity of only one side of the brain.

23. Transcranial doppler : Measures ipsilateral middle cerebral artery blood flow velocities. Detect and quantify embolic signals, which almost always arise during dissection and/or angioplasty. Disadvantage - technically demanding. SSEPs : Reflects the presence of intact sensory pathways from a stimulated peripheral nerve to the cortex where electrical activity is monitored. Distortion of certain waveforms is associated with ischemia May be used when ischemia cannot be detected during barbiturate anesthesia ( isoelectric EEG ) Relative advantage over the EEG in patients with prior CVAs

24. Cerebral oximetry / Near Infrared Spectroscopy (NIRS) : Noninvasive, continuous, and easy to use. A relative decrease of 20% or greater in regional cerebral oxygen saturation (rSO ₂ ) suggested cerebral ischemia. Low positive predictive value and low specificity. If used exclusively - unnecessary shunting and lead to over- shunting of patients. Internal carotid stump pressure : Pressure in the portion of the internal carotid artery cephalad to the carotid cross-clamp Used to determine whether cerebral blood flow (CBF) during cross clamping was adequate to avoid neuronal damage. Reflects pressure transmitted through collateral vessels. Anesthetic agents can alter carotid stump pressure without changing regional CBF

25. General anesthesia : Regional anaesthesia : AdvantagesDisadvantages A still patient A quiet operative field, Early control of the airway and ventilation, Ability to “protect” the brain form ischemia Inability to perform repeated neurologic evaluations during surgery. Therefore, patients receiving general anesthesia should have their CBF or function monitored AdvantagesDisadvantages Patient remains awake allowing for repeated neurologic evaluations Loss of patient cooperation. Alteration of mental status with cerebral ischemia, Seizures Cannot provide brain protection

26. Patients present hypertensive despite having taken their morning antihypertensive and antianginal medications. Most prone to hypotension after the induction of general anesthesia. Propofol / etomidate may be used for induction. During the induction and intubation sequence, the patient's blood pressure is kept in normal range by the use of vasopressors - phenylephrine and vasodilators - nitroglycerin or sodium nitroprusside. Phenylephrine - α agonist, has no direct effect on the cerebral vasculature; cerebral perfusion is increased by an elevation in the CPP. It increases blood pressure, cerebral perfusion pressure, stump pressure, and regional cerebral blood flow (CBF). Fluid overload may contribute to postop hypertension.

27. Trachea may be sprayed with 100 mg lidocaine to minimize stimulation by the endotracheal tube during surgery. LMA  ↓ hypertensive & tachycardic episodes Sudden onset bradycardia & hypotension may be caused by baroreceptor reflexes with surgical irritation of carotid sinus. - surgeons may infiltrate the carotid bifurcation with 1% lidocaine to attenuate this response. - this may result in more postoperative hypertension. Relaxant.

28. Maintenance of a “light” anesthetic appears to have several advantages over deep anesthesia. It allows ischemic patterns on the EEG to be recognized easily. Facilitates maintenance of the patient's blood pressure. Light anesthetic, compared to a deep anesthetic using phenylephrine to maintain blood pressure, results in a lower incidence of perioperative myocardial infarction (MI). Any anesthetic regimen is suitable if it provides hemodynamic stability, does not exacerbate cerebral ischemia, and allows for a prompt emergence from anesthesia at the conclusion of surgery

29. Hypercapnia  dilates cerebral blood vessels  increases cerebral blood flow. In CEA, may be detrimental if it dilates vessels in normal areas of the brain while vessels in ischemic brain areas that are already maximally dilated cannot respond  “steal phenomenon” Hypocarbia  vasoconstriction  worsens cerebral ischemia ‘ maintenance of NORMOCARBIA’ Moderate hyperglycemia may worsen ischemic brain injury.

30. Hypothermia can depress neuronal activity sufficiently to decrease cellular oxygen requirements below the minimum levels normally required for continued cell viability. In theory, hypothermia represents the most effective method of cerebral protection. Almost all commonly used anesthetic agents reduce cerebral metabolism, thereby decreasing the brain's requirements for oxygen. Desflurane & Sevoflurane compared to Isoflurane allow for faster emergence & recovery Volatile anaesthetics may provide preconditioning & neuronal protection by inducing nitric oxide synthase.

31. Barbiturates - offer a degree of brain protection during periods of regional ischemia. - Thiopental decreases cerebral metabolic oxygen requirements to about 50% of baseline. - These maximally achievable reductions in oxygen requirements correspond to a silent EEG. Etomidate and Propofol decrease brain electrical activity and decrease cellular oxygen requirements. Etomidate preserves cardiovascular stability and beneficial in a patient population whose cardiac reserves are often limited. Propofol allows rapid awakening of pt & neurological assessment at the end of surgery. Cerebral autoregulation is impaired by sevoflurane but preserved under propofol-remifentanil anesthesia Propofol-remifentanil  lower incidence of MI

32. A sensory blockade is required in the C2 to C4 dermatomes. This can be accomplished with either deep or superficial cervical plexus blocks. In performing the blocks, care must be taken not to excessively palpate the neck, because part of the plaque in the carotid artery may dislodge and embolize.

33. Superficial cervical plexus block Performed by infiltrating along with middle third of the posterior border of the sternocleidomastoid muscle with local anesthesia

34. Deep cervical plexus blocks Performed with three injections along a line drawn from Chassaignac's tubercle (C6) to the mastoid process. Alternatively, a single injection of local anesthetic can be made on the line between the mastoid process and Chassaignac's tubercle at the level of C4 with the needle directed medially and slightly caudad.

35. Superficial cervical plexus block may be combined with GA - reduces postop opioid requirements - reduces PaCO ₂ - increases patient satisfaction with analgesia Deep cervical plexus block - does not increase the patients comfort during procedure compared to superficial cervical plexus block. - increases complications from block placement - rate of conversion to GA is more ( 2% vs. 0.5%)

36. α₂ agonists may be used for sedation Dexmedetomidine reduces ischemic damage after transient and permanent ischemia. Dexmedetomidine has been shown to reduce arousal and decrease CBF Clonidine @ 1µg/kg/hr suppresses the hyperadrenergic response to CEA GA + superficial cervical plexus block + clonidine = hemodynamic stability Choice of anesthetic technique should take into account the preference of the surgeon and the experience and expertise of the anesthesiologist.

37. Common problems : - new neurologic dysfunction - hemodynamic instability - respiratory insufficiency Other problems : - temporary cranial nerve injuries - temporary marginal mandibular nerve deficits - temporary & permanent post. Auricular nerve deficits - mild cervical numbness Hematomas - 1% Headache, wound infection

38. Hyperperfusion syndrome - headache & hypertension Results from blood flow to the brain that is greatly in excess of its metabolic needs following CEA. May not occur until several days after surgery present with severe ipsilateral headache and can progress to develop signs of increased cerebral excitability or frank seizures. Transcranial Doppler - role in predicting which patients will develop this syndrome. Steroids may be used in the treatment of hyperperfusion syndrome.

39. Hypertension is more common than hypotension after CEA Poorly controlled preoperative hypertension. Acute tachycardia and hypertension may precipitate acute myocardial ischemia and failure It may lead to cerebral edema and/or hemorrhage Post-CEA hypertension is significantly associated with adverse events like stroke or death Exclude and/or treat other causes of hypertension such as bladder distention, pain, hypoxemia, and hypercarbia. Lower the pressures to preop values most often with labetalol in 5-mg increments In patients with reactive airways disease / bradycardia - Hydralazine Usually, the hypertensive episode has its peak 2 to 3 hours after surgery, but in individual cases it may persist for 24 hours.

40. Postoperative hypotension is less common. Causes : residual effects of anesthesia drugs, overzealous treatment of hypertension, baroreceptor resetting after increase in the flow 12-lead ECG should be obtained in the recovery room in hemodynamically unstable patients because significant hypertension or hypotension can be caused by MI Postoperative respiratory insufficiency may be caused by recurrent laryngeal nerve or hypoglossal nerve injury, a massive hematoma, or deficient carotid body function

41. Hematoma: small hematomas - venous oozing - treatment : gentle digital compression / reversing residual heparin with protamine Expanding hematoma - tracheal compression - immediate evacuation More common with patch angioplasty

42. Unilateral loss of carotid body - not very significant Bilateral loss of carotid body - loss of hypoxic drive Supplemental oxygen to be given routinely Drugs causing resp. depression should be avoided.

43. The patient who awakens with a major new neurologic deficit or who develops a suspected stroke in the immediate postoperative period represents a surgical emergency. Inadequate collateral flow, carotid thrombosis may cause postoperative stroke Prompt surgical reexploration can produce significant neurologic improvement. If the deficit - focal and minor, it is most commonly due to microembolization. Noninvasive assessment of internal carotid flow and anticoagulation after exclusion of a hemorrhagic brain lesion is the indicated treatment

44. For patients undergoing neck exploration for a wound hematoma following CEA - tracheostomy / cricothyroidotomy tray should be available. Management of a difficult airway Esmolol - control of hyperdynamic cardiovascular responses during awake intubation Difficulty in managing airway - wound is opened & drained externally  tracheal intubation before GA is induced EMERGENCY CAROTIDENDARTERECTOMY : Patient may have full stomach -- aspiration prophylaxis Anesthetic technique is similar.

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