1. Teaching NeuroImages Neurology Resident and Fellow Section © 2014 American Academy of Neurology MRI-visible Virchow-Robin Perivascular Spaces in Cerebral Small Vessels Disease

2. Vignette We describe the neuroimaging findings of two patients who were diagnosed with small-vessel pathologies: probable CAA (Case 2, Panels C&D), probable CAA and hypertensive arteriopathy (Case 1, Panels A&B). A 69-year-old woman presented with left cortical intracerebral hemorrhage (Case 1). She fulfilled the diagnostic criteria of probable CAA and hypertensive arteriopathy A 71-year-old woman presented with cerebellar intracerebral hemorrhage. She fulfilled the diagnostic criteria. Voumvourakis K. et al. © 2014 American Academy of Neurology

3. Imaging Voumvourakis K et al. © 2014 American Academy of Neurology

4. MRI-visible perivascular spaces in cerebral small vessels disease MRI-visible perivascular-spaces (PVS) in centrum-semiovale white-matter (CS) have been proposed as novel neuroimaging marker for cerebral-amyloid-angiopathy (CAA). 1,2 Progressive b-amyloid deposition in small cortical and leptomeningeal arteries in CAA may gradually impair perivascular-drainage and cause retrograde PVS-dilation. 1,2 Voumvourakis K et al. © 2014 American Academy of Neurology