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55-year-old man with progressive dementia Teaching NeuroImages Neurology Resident and Fellow Section.

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Presentation on theme: "55-year-old man with progressive dementia Teaching NeuroImages Neurology Resident and Fellow Section."— Presentation transcript:

1 55-year-old man with progressive dementia Teaching NeuroImages Neurology Resident and Fellow Section

2 Vignette A 55-year-old African-Canadian man presented with diabetic ketoacidosis History of insulin-dependent diabetes mellitus and alcohol abuse Progressive cognitive decline (severe impairment of orientation/attention/recall/comprehension/nam ing) over the previous five years resulting in long- term care placement Aside from pigmentary retinopathy, general examination was unremarkable Parks et al.

3 Imaging Parks et al.

4 Imaging Parks et al.

5 Neurodegeneration with brain iron accumulation in aceruloplasminemia Ceruloplasmin undetectable, low serum iron, low serum copper, and 10-fold increase in serum ferritin Diagnosed with aceruloplasminemia Iron chelation was not administered given advanced dementia at presentation Parks et al.


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