1. Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Choice of Estimated Glomerular Filtration Rate Equation Impacts Drug-Dosing Recommendations and Risk Stratification in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Interventions J Am Coll Cardiol. 2015;65(25):2714-2723. doi:10.1016/j.jacc.2015.04.037 Scatterplots of eGFR and CrCl by Various Formulas C-G = Cockcroft-Gault; CKD-EPI = Chronic Kidney Disease Epidemiology Collaboration; CrCl = creatinine clearance; eGFR = estimated glomerular filtration rate; MDRD = Modification of Diet in Renal Disease. Figure Legend:

2. Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Choice of Estimated Glomerular Filtration Rate Equation Impacts Drug-Dosing Recommendations and Risk Stratification in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Interventions J Am Coll Cardiol. 2015;65(25):2714-2723. doi:10.1016/j.jacc.2015.04.037 Confusion Matrices of Patients Classified by CKD Stages by eGFR Categories BSA = body surface area; CKD = chronic kidney disease; G1 to G5 = stage of CKD as defined by eGFR category; other abbreviations as in Figure 1. Figure Legend:

3. Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Choice of Estimated Glomerular Filtration Rate Equation Impacts Drug-Dosing Recommendations and Risk Stratification in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Interventions J Am Coll Cardiol. 2015;65(25):2714-2723. doi:10.1016/j.jacc.2015.04.037 NRI Compared With CKD-EPI Using CKD Stages Defined by eGFR and CrCl Values AKI = acute kidney injury; BIS1 = Berlin Initiative Study; NRD = new requirement for dialysis; NRI = net reclassification index; other abbreviations as in Figures 1 and 2. Figure Legend:

4. Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Choice of Estimated Glomerular Filtration Rate Equation Impacts Drug-Dosing Recommendations and Risk Stratification in Patients With Chronic Kidney Disease Undergoing Percutaneous Coronary Interventions J Am Coll Cardiol. 2015;65(25):2714-2723. doi:10.1016/j.jacc.2015.04.037 Impact of eGFR Equation on Drug Dosing The choice of estimated glomerular filtration rate (eGFR) equation varies widely among institutions, physicians, and pharmacists, and the use of an inappropriate equation could lead to large discrepancies in drug dosing and potential patient harm. Standardization of eGFR equation use among clinicians and new drug pharmacokinetic design could clarify equation selection and reduce possible drug-dosing errors. Figure Legend: