1. Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Prognostic Value of N-Terminal Pro–B-Type Natriuretic Peptide for Death and Cardiovascular Events in Healthy Normal and Stage A/B Heart Failure Subjects J Am Coll Cardiol. 2010;55(19):2140-2147. doi:10.1016/j.jacc.2010.01.031 Age- and Sex-Specific 80th Percentile Values for Plasma NT-proBNP Age- and sex-specific 80th percentile values for plasma N-terminal pro–B-type natriuretic peptide (NT-proBNP) in the total study sample excluding subjects with stages C and D heart failure or creatinine >2.0 (n = 1,991). Solid line = female; dashed line = male. Figure Legend:

2. Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Prognostic Value of N-Terminal Pro–B-Type Natriuretic Peptide for Death and Cardiovascular Events in Healthy Normal and Stage A/B Heart Failure Subjects J Am Coll Cardiol. 2010;55(19):2140-2147. doi:10.1016/j.jacc.2010.01.031 Cumulative Survival and Event-Free Survival in the Healthy Normal Subgroup Kaplan-Meier curves for unadjusted cumulative incidence in the healthy normal subgroup (n = 703) for (A) death, (B) heart failure, (C) cerebrovascular accident, and (D) myocardial infarction according to plasma N-terminal pro–B-type natriuretic peptide (NT- proBNP) values above the age- and sex-specific 80th percentile (thick line) and below it (thin line). Follow-up results are truncated after 10 years. Age- and sex-specific 80th percentile NT-proBNP values are shown in Figure 1. The average overall 80th percentile value was 196 pg/ml for women and 125 pg/ml for men. Figure Legend:

3. Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Prognostic Value of N-Terminal Pro–B-Type Natriuretic Peptide for Death and Cardiovascular Events in Healthy Normal and Stage A/B Heart Failure Subjects J Am Coll Cardiol. 2010;55(19):2140-2147. doi:10.1016/j.jacc.2010.01.031 Cumulative and Event-Free Survival in the Stage A/B Heart Failure Subgroup Kaplan-Meier curves for unadjusted cumulative incidence in the stage A/B heart failure subgroup (n = 1,228) for (A) death, (B) heart failure, (C) cerebrovascular accident, and (D) myocardial infarction according to plasma N-terminal pro–B-type natriuretic peptide (NT-proBNP) values above the age- and sex-specific 80th percentile (thick line) and below it (thin line). Follow-up results are truncated after 10 years. Age- and sex-specific 80th percentile NT-proBNP values are shown in Figure 1. The average overall 80th percentile value was 196 pg/ml for women and 125 pg/ml for men. Figure Legend: