1. The future of the NIHR NIHR: 10 years of delivering health and care research for the nation QEII Centre, London Wednesday 18 May 2016 Professor Chris Whitty CB FMedSci Chief Scientific Adviser Department of Health

2. Building on 10 remarkable years The extraordinary advances in health are based on evidence and science, properly applied. Most health interventions depend on science from multiple disciplines from the most basic to the most applied. Future advances need to take account of changing need, new threats, new scientific opportunities.

3. Age-standardised mortality rates England and Wales (ONS 2014)

4. Ten leading causes of death in females, 2003-2013, England & Wales (ONS)

5. Must take account of distribution of need. Dementia in women (L), heart disease (R)

6. Population 85 and over: 1992, 2015, 2033 (ONS).

7. MRC Research spend 2013/2014 Spend by UK public funder Applied research Basic research NIHR

8. NIHR Biomedical Research Units NIHR Health Protection Research Units NIHR Biomedical Research Centres NIHR Blood and Transplant Research Units NIHR Healthcare Technology Co- operatives NIHR Diagnostic Evidence Co-operatives NIHR-supported Clinical Research Facilities NIHR School for Public Health Research NIHR School for Primary Care Research NIHR/CR-UK Experimental Cancer Medicine Centres NIHR Surgical Reconstruction and Microbiology Research Centre NIHR Collaborations for Leadership in Applied Health Research and Care NIHR-Supported Facilities Newcastle Leeds Leicester Peninsul a Bradford Manchester Sheffield Liverpool Nottingham Birmingham Oxford Cambridge London Bristol Brighton Southampton Exeter

9. NIHR Clinical Research Network 15 Local Clinical Research Networks (LCRNs). Boundaries align with AHSNs. Essential for the testing of new interventions for the NHS in areas of clinical need. Also important for industry and charities.

10. Research training has to be appropriate for when trainees become independent scientists. Need to adapt to current pressures on clinical and non-clinical scientists. Need to address the falloff in women in science at postdoctoral level. The future of the future: training

11. Many fields rapidly progressing driven by new and old sciences, supported by NIHR. This will continue over the next 10 years. Stroke mortality