1. HYMS: the future

2. What we have Established teaching programme and innovative curriculum Good joint working with the NHS Excellent financial arrangement with NHS for SIFT A strong national ‘brand’ for medical education moving onto the international stage A sound management system for undergraduate teaching focussed on operational rather than strategic issues.

3. Medical education and research are not independent but rather inter-dependent ‘Properly planned and carefully conducted medical education is the essential foundation of a comprehensive health service’ ‘In the teaching hospitals care of patients and furtherance of teaching and research should receive equal emphasis’ ‘The further you look back the further you can look forward’ (Churchill 1944) Goodenough Report (1944) Resonates with current priorities –‘Tomorrows Doctors’ & BIGT report 2003 improved national health and increased national wealth Partnership is essential HYMS already highly rated for medical education, so the focus is now on the research component

4. What we don’t have Well developed HYMS research base Facility for experimental medicine to exploit links with Biology and imaging Joint research with NHS Postgraduate degrees - research and taught Research brand for HYMS Sufficient intercalated degrees Management structure for strategic research development –Record of grants or publication Research income –nil despite around 15 research active academics Physical focus for research

5. Priorities Create a high quality medical research reputation, environment and culture for HYMS –Exploit existing strengths –Appointments in key areas –Identify research opportunities –Provide research infrastructure Facilities and physical focus Management –Research degrees and taught PG courses –Intercalated degrees Further investment in medical education to maintain an innovative curriculum Increased income to support continuing investment in research and education

6. What does research in a traditional Medical School look like? 1 Cardiovascular medicine 2 Cancer studies 3 Infection and Immunity 4 Other hospital based subjects 6 Epidemiology / public health 7. Health services research 8. Primary care 9. Psychiatry /clin psychology 14. Biological sciences 15. Preclinical & human biological science

7. Creating a presence in medical research York recognised as internationally leading in –Health Sciences –Epidemiology, public health, health policy, health economics, health services research, clinical trials –Biology –Infection & Immunity, Cancer, reproduction –Psychology HYMS has invested posts in several of these areas, but not seen as part of the medical school HYMS presents the opportunity to enhance medical research by joint working Need to ’badge’ existing medical research under HYMS

8. Research Areas for Development; National priorities -MRC Ensure advances at the molecular level are extended quickly to increase our understanding of how cells, organs and organisms behave in health and disease. Major emphasis on translating this laboratory-based work into new and improved treatments, interventions and healthcare service Current priority areas include: –Clinical and public health research –Infections and vaccine research –Global health –Biomarkers Resonate well with research in York But need for translation - the role of HYMS

9. Translational Research…….. From molecule to man, from patient to population Upon this gifted age, in its dark hour, Rains from the sky a meteoric shower Of facts...they lie unquestioned, uncombined. Wisdom enough to leech us of our ill Is daily spun; but there exists no loom To weave it into fabric. Edna St Vincent Millay from ‘Upon this age that never speaks its mind’

10. HYMS: Experimental Medicine Unit Experimental medicine is investigation in humans to identify mechanisms of disease, to test the validity and importance of new discoveries or treatments Translates biological findings into man –proof of concept Followed by clinical trials, to translate into clinical practice York is key for experimental medicine –Facility needed to study small numbers of patients in depth –proximate to biology and imaging facilities

11. HYMS: clinical trials Population base with high morbidity –Not exploited in trials Clinical Research facility in Hull costing £6.5M using HYMS NHS R & D and charitable funding Change in NHS R & D funding and management –Directed research and clinical trials Development of HYMS Comprehensive Local Research Network proposal for the region

12. R&D Strategy Changes and NHS Trusts: The opportunity All R&D Funding being withdrawn and reallocated to follow activity Strategic aims of redistribution include: –Concentrate funding in key centres of international standing –5 generic Biomedical Research Centres - Cambridge, Guys, Hammersmith, Oxford, UCL –Improve equity of population access to clinical research by element of per capita funding NIHR – Faculty, Projects & Programmes, Facilities The Comprehensive Research Network –National requirements for Comprehensive Local Research Networks Core funding ~ £270-300K pa per CLRN –Pays for management of the Network, not of research Per capita funding –£1.25m in this area, for 1.64m population Increased activity should equal increased income

13. NHS R & D Transitional Funding allocations in England by population - 2006/7 (£ per capita) England10.39 Greater London46.50 England excluding Greater London 4.22 Yorkshire and Humber4.56 NE Yorks & N Lincs0.87

14. UK Medical Research Funding % by region or city S/E England London 47.8 33.3 Scotland Edinburgh 13.1 5.6 N/W England Manchester 6.3 5.2 Yorkshire and Humber Leeds 5.7 2.9 W Midlands Birmingham 2.7 2.3

15. Recruitment: Key to Realising the Opportunity ‘ Willing is not enough; we must do’ Goethe To link with Biology (IIU) at York –Chair of Experimental Medicine, –Senior Lecturers in Clinical subjects related to immunology eg renal medicine, immunohaematology, –GUM chair and SL To link with Health Science at York Chair and SL in epidemiology and public health To link with Psychology & YNIC Chair and support posts in neuroscience Work with NHS Trusts to align service and HYMS agenda for recruitment where possible Parallel developments in Hull

16. HYMS: The future Continued innovative education Research reputation –Presentation & Organisation –Facilities - HEMU –Recruitment Success in Education and Research brings further investment and a virtuous cycle of development benefiting HYMS, the Universities, the NHS and the population.

17. Network Board Accountable to UKCRN Accountable to partner organisations East Yorkshire Research Management Research Nursing Administration North Yorkshire Research Management Research Nursing Administration North Lincs Research Management Research Nursing Administration CLRN Executive Committee Core Management Team Research Facilitators Monitoring Officers Network Trust R&D Committee Locality Teams Proposed HYMS CLRN Structure