2. ASTHMA Definition: Asthma is a chronic lung disease due to inflammation of the airways resulted into airway obstruction. The obstruction is reversible. Asthma is the most common chronic disease particularly among children. Symptom: Wheeze Tightness in the chest Shortness of breath Sometimes nocturnal symptoms

3. Pathology of Asthma Inflammation Airway Hyper-responsivenessAirway Obstruction Symptoms of Asthma

4. ASTHMA

5. Asthma Increasing rates Asthma rates have been increasing worldwide for both adults and children, males and females and in different race and ethnicities. It is estimated that the number of people with asthma worldwide will increase by 25% in the next 15 years.

6. Child and Adult Asthma Prevalence United States, 1980-2007 12-Month Lifetime Child  Adult Source: National Health Interview Survey; CDC National Center for Health Statistics Current

7. Asthma Prevalence by Sex United States, 1980-2007 12-Month Lifetime Female  Male Source: National Health Interview Survey; CDC National Center for Health Statistics Current

8. ASTHMA Causes: Genetic Atopy Childhood respiratory infections Exposure to allergens

9. ASTHMA Asthma Triggers: Types of substanceExample Air pollutantsTobacco smoke, perfumes, wood dusts, gases, chemicals, solvents, paints PollenTrees, flowers, weeds, plants Animal danderBirds, cats, dogs MedicationAspirin, anti-inflammatory drugs, B-blockers FoodEggs, nuts, wheat

10. ASTHMA MANIFESTATION OF SEVERE ASTHMA History - Frequent use of inhaler - Previous ICU admission - Patient on steroid - Not responding to initial inhalation therapy

11. ASTHMA SEVERE ASTHMA: Physical Examination - HR > 115/min - RR > 30/min - Pulsus paradoxus > 10 mmHg - Unable to speak - Cyanosis - Silent chest

12. Asthma Spirometer

13. Asthma Arterial Blood Gases Acideamia Hypoxiamia Hypercarpia

14. FVC FEV 1 NORMAL = FVC > 75% 0 1 2 3 4 5 6 7 8 TIME 100 75 50 25

15. FVC FEV 1 Airway Obstruction = FVC < 75% FEV 1 0 1 2 3 4 5 6 7 8 TIME 100 75 50 25

16. ASTHMA Poorly controlled asthma leads to: Increased visits to doctors, hospital ER Hospitalizations Limitation in daily activities Lost work days Lower quality of life Death

17. ASTHMA Treatment: Patient/Doctor Relationship -Educate continually -Include the family -Provide information about asthma -Provide training in self-management skills

18. ASTHMA Treatment: Exposure Risk Reduce exposure to indoor allergens Avoid tobacco smoke Avoid vehicle emission Identify irritants in the workplace

19. ASTHMA Treatment Takes daily over long period of time Used to reduced inflammation, relaxed airway muscles and improve symptoms and lung function - Inhaled corticosteroids - Long-acting beta 2 -agonists - Leukotrienes modifiers

20. Asthma Quick Reliever Used in acute attacks Short acting beta 2- agonists Begins to work immediately and peaks at 5-10 minutes

21. Asthma Inhalers and Spacers Spacers can help patients who have difficulty with inhaler use and can reduce potential for adverse effects from medication.

22. Asthma Nebulizers Machine produces a mist of medication Used for small children or for severe asthma No evidence that it is more effective than an inhaler used with spacers

23. Asthma Anti- Ig E For treatment of moderate to severe allergic asthma For treatment of those who do not respond to high dose of corticosteroids

24. ASTHMA Treatment of Acute Attack of Asthma: - O 2 Supplementation - Inhaled Ventolin -Inhaled steroids - Inhaled Atrovent - IV Steroids For severe cases consider: - IV Mg SO 4 - BiPAP - Mechanical Ventilation – for those who do not respond the above treatments.

26. Chronic Obstructive Pulmonary Disease (COPD) Limitation of expiratory flow Chronic progressive disease Associated with airway inflammation Generally irreversible airflow obstruction Related to smoking

27. Chronic Obstructive Pulmonary Disease (COPD) Emphysema Chronic bronchitis Small airway disease

28. COPD COPD Facts: COPD is the 4 th leading cause of death in the United States COPD has higher mortality rate than asthma Leading cause of hospitalization in the US 2 nd leading cause of disability

29. COPD COPD Risk Factors Smoking: most common cause Environmental exposure - chemicals. Dust, fumes - second hand smoke Alpha-1 anti-trypsin (AAT) deficiency

30. Chronic Obstructive Pulmonary Disease (COPD)

31. COPD Alpha 1 Anti-Trypsin (AAT) - is a serine protease inhibitors -Inhibit neutrophil elastase which break down elastin -Synthesized and secreted by hepatocytes -PiZZ phenotype is associated with low plasma concentration of AAT i.e. associated with development of emphysema

32. Emphysema

38. COPD Clinical Picture Dyspnea-progressive Cough with or without expectoration Wheezing Loss of weight Hypercapnia>changes in central nervous system Barrel chest

39. COPD

40. Chronic Bronchitis Definition Cough for 3 months in a year for 2 consecutive year

41. Chronic Bronchitis

43. COPD COPD Treatment Inhalers (bronchodilators) Anti-inflammatory medications Anti-cholinergic Theophylline therapy Oxygen therapy Antibiotics Pulmonary rehabilitation Lifestyle changes - give up smoking BiPAP Therapy for severe patients

44. COPD

45. COPD Treatment Ventolin nebulization Steroid inhalation Atrovent inhalation Systemic steroid Non-invasive mechanical ventilation if the above measures were not effective.

46. COPD Home Oxygen Therapy

47. COPD Oxygen therapy For COPD with severe hypoxemia -It improves survival -It improves quality of life -Indicated in patient with PaO 2 < 60 mmHg

48. COPD Non-invasive Mechanical Ventilation Treatment

49. COPD Rehabilitation program -Decreased symptoms -Decreased anxiety an depression improved quality of life -Decreased hospitalization -Increase exercise capacity

50. Changes in FEV 1 with Aging ( Smoker vs Non-Smoker)