1. PHR 301: MEDICINAL CHEMISTRY 1 Dr. M Zulfiquer Hossain (ZQH) Associate Professor Department of Pharmacy Room UB31108 zulfiquer@bracu.ac.bd

2. Student Introductions Please introduce yourself Tell me Why you are here What you want to learn in this course

3. Course Logistics Class Schedule Sunday and Tuesday: 12:30 – 1:50 pm Consultation Hours: Sunday: 9:30 am – 10:50 am Tuesday: 2 pm – 3:20 pm Monday and Wednesday: 11 am – 12:20 pm and 3:30 – 4:50 pm

4. Aims of the Course Medicinal Chemistry I is the first course of a three-part series on Medicinal Chemistry The primary goal of this course is to elaborate the fundamental principles of advanced organic chemistry that govern the design, development, and synthesis of therapeutic drugs in the modern world This course will provide a mechanistic understanding of the major functional groups of organic chemistry, their characteristic reaction types, and their relevance to medicinal chemistry The course will end with an overview of biochemical macromolecules and their biosynthesis and reactions

5. Learning Outcomes By the end of the semester, students will be able to: Demonstrate a clear understanding of the general principles that govern reactions in organic chemistry Sketch reaction mechanisms, predict products, and list clinical/biochemical significance for each of the major reaction types studied in the course Propose pathways of synthesis for the major classes of organic compounds Apply their knowledge of organic chemistry to the study of biochemical macromolecules: carbohydrates, lipids, proteins, and nucleic acids

6. Course Policies Lectures will cover every topic of the course. If I do not cover a topic, it will not be on exams Lecture outlines will be available on TSR: TSR > SPRING > PHR > ZQH > PHR 301 However, since organic chemistry is best learned by doing, I will use mostly the whiteboard in class and encourage you to take notes I will emphasize active learning during lecture Short in-class exercise Pair-share or small-group activity I will encourage you to form 5-member study-groups. I will make the grading scheme available after every exam Attendance is mandatory. If a student misses more than 30% of the classes, s/he will not be allowed to take the final examination No makeup midterm will be allowed unless the student applies to the Department Chair at least 7 days before the exam You are welcome to bring a copy of the periodic table to an exam

7. Textbooks Advanced Organic Chemistry. A. Bahl and B.S. Bahl. Revised Multicolor Edition. S. Chand. 2010. Organic Chemistry. F. A. Carey and R. M. Giuliano. 9 th Edition. McGraw Hill. 2013. Student Online Learning Center: http://highered.mheducation.com/sites/0073402745/student_view0/index.html http://highered.mheducation.com/sites/0073402745/student_view0/index.html Organic Chemistry. Robert Thornton Morrison and Robert Neilson Boyd. 6th edition. Prentice- Hall of India, Private Limited. Lehninger Principles of Biochemistry. David L. Nelson and Michael M. Cox. 6 th Edition. W. H. Freeman and Company. 2012. Willson and Gisvold’s Textbook of Organic, Medicinal, and Pharmaceutical Chemistry. J. N. Delgado and W. A. Remers. 12 th Edition. LippincottRaven. 2011.

8. Grading Procedures AttendanceMarks 90% and above5 85% to less than 90%4 80% to less than 85%3 75% to less than 80%2 70% to less than 75%1 Less than 70%0 Section Weightage % 1. Class tests/Problem Set15 2. Attendance5 3. Mid Term Examination30 4. Final Examination (comprehensive)50 Total Marks 100 Credit for Attendance: Distribution of Points for Final Grade: Modified from Course Outline Template. Dr. Eva Kabir, Chair, Department of Pharmacy

9. Grading Scale Letter GradeGP 90-100=A(4.0)Excellent 85-< 90=A-A- (3.7) 80-< 85=B+B+ (3.3) 75-< 80=B(3.0)Good 70-< 75=B-B- (2.7) 65-< 70=C+C+ (2.3) 60-< 65=C(2.0)Fair 57-< 60=C-C- (1.7) 55-< 57=D+D+ (1.3) 52-< 55=D(1.0)Poor 50-< 52=D-D- (0.7) <50 =F(0.0)Failure P:Pass I:Incomplete W:Withdrawal R : Retaken GPA Computation The Grade Point Average (GPA) is computed in the following manner: GPA = Sum of (Grade points x Credits)/ Sum of Credits Attempted Source: Course Outline Template. Dr. Eva Kabir, Chair, Department of Pharmacy

10. Academic Integrity “Each student in this course is expected to abide by the BRAC University Code of Academic Integrity. Any work submitted by a student in this course for academic credit will be the student's own work. Also refer to plagiarism policy that will be on the web. “You are encouraged to study together and to discuss information and concepts covered in lecture and the sections with other students. You can give "consulting" help to or receive "consulting" help from such students. However, this permissible cooperation should never involve one student having possession of a copy of all or part of work done by someone else, in the form of an e-mail, an e-mail attachment file, a diskette, or a hard copy. “If copying occurs, both the student who copied work from another student and the student who gave material to be copied will both automatically receive a zero for the assignment. Penalty for violation of this Code can also be extended to include failure of the course and University disciplinary action. During examinations, you must do your own work. Talking or discussion is not permitted during the examinations, nor may you compare papers, copy from others, or collaborate in any way. Any collaborative behavior during the examinations will result in failure of the exam, and may lead to failure of the course and University disciplinary action.” Reference: Course Outline Template. Dr. Eva Kabir, Chair, Department of Pharmacy

11. Let’s get started!