1. RENAL FAILURE & TRANSPLANTATION RENAL FAILURE & TRANSPLANTATION

2. Renal Failure Reduced clearance of certain solutes principally excreted by the kidney The most common indicators are urea & creatinine RF could be acute or chronic

3. Causes of end stage renal failure - DM 36% - Hypertensive nephrosclerosis 30% - chronic glomerulonephritis 24% - Autosomal dominant polycystic kidney disease 12% -chronic pyelonephritis In pediatric age group ( <18 year ) congenital causes predominate like cong. hypoplasia.

4. Treatment of end stage CRF Treatment is by hemodialysis, peritoneal dialysis, or renal transplantation

5. Renal transplantation Renal Transplantation is the treatment of choice & the most cost effective treatment for end stage renal failure. The upper age limit for renal transplantation is 70 year of age in average

7. DONER RECEPIENT

8. recepient evaluation: Cardiac status Malignant diseases: waiting time : 1 – 2 year for low metastatic potential 5 – 6 year for high risk tumors Infections GIT diseases like peptic ulcer GU abnormalities : MCUG, URODYNAMIC STUDY

9. Pretransplant bilateral native kidney nephrectomy Seldom required Indications: Pyelonephritis Medically uncontrolled renin mediated hypertension Malignant disease Nephrotic syndrome Extremely large polycystic kidney

10. Types of donors for renal transplantation Living related donors : Allograft half life is 10 year longer than cadaveric renal donation Living unrelated donors Cadaveric donors :

11. Contraindications for renal transplantation Active infections including AIDS Active malignant diseases

12. the donor is always left with the better kidney Left kidney is prefered due to longer renal vein

13. Investigations & HLA tissue matching Tissue matching is performed for HLA – A,B,&DR antigen that are found on the 6th chromosome ABO blood grouping & cross matchin

14. Types of rejections Hyperacute rejection Acute rejection Chronic rejection

15. Hyperacute rejection incidence 1/1000 analogous to blood transfusion reaction, occurs immediately,preformed Ab against HLA expressed on donor renal vascular endothlium occurs as soon as blood flow to the donor kidney is established treatment : immediate transplant removal

16. Acute rejection occurs between 1 st week- 1 month occurs in 25 – 55% of patient Diffrential diagnosis : ATN, ureteral obst, drugs toxisity Clinically : febrile, tenderness over the graft impaired renal function,decrease urine output. Diagnosis : renal biopsy treatment.. by steroids & immunosuppressants

17. Chronic rejection Defined as a gradual progressive loss of renal function that cannot be attributed to another cu. there is no definitive treatment for this type of rejection retransplantation to be consedered

18. Immunosupression : Focused on preventing & reversing acute rejection Agents used in 3 ways induction : immediately after Tx like Azathioprine & steroids maintenance : initiated once creatinine in normalised like Azathioprine & steroids, cyclosporin A treatment of acute rejection like steroids

19. Complications of renal transplantation Technical 1.Delayed transplant renal artery stenosis 2.Anastamotic leak 3.Anastamotic or ureteral stricture 4.Ureteral obstruction 5.Ureterovesical disruption 6.Lymphocele

20. Complications of renal transplantation,cont Non technical Infections Cancers: lymphoma, Kaposi sarcoma