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Chapter 7: Pediatric ESRD 2014 A NNUAL D ATA R EPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE.

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Presentation on theme: "Chapter 7: Pediatric ESRD 2014 A NNUAL D ATA R EPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE."— Presentation transcript:

1 Chapter 7: Pediatric ESRD 2014 A NNUAL D ATA R EPORT V OLUME 2: E ND -S TAGE R ENAL D ISEASE

2 Vol 2, ESRD, Ch 72 Data Source: Reference tables D3-D5, D7-D9, and special analyses, USRDS ESRD Database. Peritoneal dialysis consists of continuous ambulatory peritoneal dialysis and continuous cycling peritoneal dialysis. Abbreviations: ESRD, end-stage renal disease; HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.1. Incident & December 31 point prevalent ESRD patients (aged 0-19 years) (a) Incidence of ESRD in children

3 Vol 2, ESRD, Ch 73 Data Source: Reference tables D3-D5, D7-D9, and special analyses, USRDS ESRD Database. Peritoneal dialysis consists of continuous ambulatory peritoneal dialysis and continuous cycling peritoneal dialysis. Abbreviations: ESRD, end-stage renal disease; HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.1. Incident & December 31 point prevalent ESRD patients (aged 0-19 years) (b) Prevalence of ESRD in children

4 Vol 2, ESRD, Ch 74 vol 2 Table 7.1 : Distribution of reported incident pediatric ESRD patients by primary diagnosis, (period A) and (period B) (aged 0-19 years) TransplantDied TotalIncidentAgeMaleWhiteAfrican AmOther Racefirst year Patients %Median%% % A B A B A B A B A B A B A B A B A B All ESRD (reference) 6,544 6, Diabetes Type Type Glomerulonephritis (GN) 1,541 1, GN (histologically not examined) Focal glomerular sclerosis Membranous nephropathy MPGN GN type 1, diffuse MPGN Dense deposit disease, MPGN type IgA nephropathy IgM nephropathy * Rapidly progressive GN Post infectious GN, SBE Other proliferative GN Secondary GN/vasculitis Lupus nephritis Henoch-Schonlein syndrome Scleroderma * * Hemolytic uremic syndrome Polyarteritis Wegeners granulomatosis Other vasculitis and its derivatives Goodpasture syndrome Secondary GN, other

5 Vol 2, ESRD, Ch 75 TransplantDied TotalIncidentAgeMaleWhiteAfrican AmOther Racefirst year Patients %Median%% % A B A B A B A B A B A B A B A B A B Interstitial nephritis/pyelonephritis Nephropathy caused by other agents Nephrolithiasis * Acquired obstructive uropathy Chronic pyelonephritis, reflux nephropathy Chronic interstitial nephritis Acute interstitial nephritis * * Disorders of calcium metabolism * Hypertensive/large vessel disease Unspecified with renal failure Renal artery stenosis * * Renal artery occlusion * * Cystic/hereditary/congenital diseases 2,088 2, Polycystic kidneys, adult type (dominant) Polycystic, infantile (recessive) Medullary cystic disease, inc. nephronophthisis Tuberous sclerosis * * Hereditary nephritis, Alport's syndrome Cystinosis Primary oxalosis 17 * Congenital nephrotic syndrome Drash syndrome, mesangial sclerosis Congenital ureterpelvic junction obstruction Congenital uretrovesical junction obstruction Other congenital obstructive uropathy Renal hypoplasia, dysplasia, oligonephronia Prune belly syndrome Other (congenital malformation syndromes) vol 2 Table 7.1 : Distribution of reported incident pediatric ESRD patients by primary diagnosis, (period A) and (period B) (aged 0-19 years) (cont’d)

6 Vol 2, ESRD, Ch 76 TransplantDied TotalIncidentAgeMaleWhiteAfrican AmOther Racefirst year Patients %Median%% % A B A B A B A B A B A B A B A B A B Neoplasms/tumors Renal tumor (malignant) Renal tumor (unspecified) * * Transplanted organ complication, unspecified 21 * Transplanted kidney complication Transplanted liver complication * * Transplanted heart complication Bone marrow transplant complication Miscellaneous conditions Sickle cell disease/anemia 14 * Post partum renal failure * * AIDS nephropathy Traumatic or surgical loss of kidney(s) 15 * Hepatorenal syndrome * * Tubular necrosis Other renal disorders Etiology uncertain Missing Data Source: Special analyses, USRDS ESRD Database. Abbreviations: AIDS, acquired-immune deficiency syndrome; ESRD, end-stage renal disease; GN glomerulonephritis; IgA immunoglobulin A; IgM, immunoglobulin M; MPGN, membranoproliferative glomerulonephritis; SBE, sub-acute bacterial endocarditis. *Suppressed due to inadequate sample size..Zero values in this cell. vol 2 Table 7.1 : Distribution of reported incident pediatric ESRD patients by primary diagnosis, (period A) and (period B) (aged 0-19 years) (cont’d)

7 Vol 2, ESRD, Ch 77 Data Source: Reference tables A1, E9, M1, and special analyses, USRDS ESRD Database. The rate of ESRD per million among the U.S. population age 0-19 and the rate of transplantation in dialysis patients age 0-19 at the time of transplant, 1989–2012. Abbreviations: ESRD, end-stage renal disease. vol 2 Figure 7.2 Trends in pediatric transplantation (aged 0-19 years) (a) Incidence rate of ESRD and transplant rate in children

8 Vol 2, ESRD, Ch 78 Data Source: Reference tables E2, E3, and special analyses, USRDS ESRD Database. The waiting list count provides the number of pediatric candidates aged 0-19 years on the Organ Procurement and Transplantation Network kidney transplant waiting list on December 31 of each year for first and subsequent kidney alone or kidney plus pancreas transplantation. Candidates listed at more than one center on December 31 are counted only once. There are no data available for median waiting list time for patients with prior transplants listed after Abbreviations: Tx, transplant. vol 2 Figure 7.2 Trends in pediatric transplantation (aged 0-19 years) (b) Waiting list count

9 Vol 2, ESRD, Ch 79 Data Source: Reference tables E8, E8(2), E8(3), and special analyses, USRDS ESRD Database. This figure represents kidney alone and kidney plus pancreas transplant counts for all pediatric candidates. vol 2 Figure 7.2 Trends in pediatric transplantation (aged 0-19 years) (c) Total transplants

10 Vol 2, ESRD, Ch 710 Data Source: Reference table D9. This is the cumulative count of functioning pediatric kidney and kidney-pancreas transplants. vol 2 Figure 7.2 Trends in pediatric transplantation (aged 0-19 years) (d) Total functioning transplants

11 Vol 2, ESRD, Ch 711 Data Source: Reference Table E9, and special analyses, USRDS ESRD Database. Includes transplant year between 1991–2012. vol 2 Figure 7.3 Live and deceased donor transplants in pediatric patients (aged 0-19 years) (a) Transplant rate in pediatric dialysis patients by age

12 Vol 2, ESRD, Ch 712 Data Source: Reference Table E9, and special analyses, USRDS ESRD Database. Includes transplant year between 1991–2012. vol 2 Figure 7.3 Live and deceased donor transplants in pediatric patients (aged 0-19 years) (b) Transplant rate in pediatric dialysis patients by sex

13 Vol 2, ESRD, Ch 713 Data Source: Reference Table E9, and special analyses, USRDS ESRD Database. Includes transplant year between 1991–2012. vol 2 Figure 7.3 Live and deceased donor transplants in pediatric patients (aged 0-19 years) (c) Transplant rate in pediatric dialysis patients by race

14 Vol 2, ESRD, Ch 714 Data Source: Special analyses, USRDS ESRD Database. Includes incident ESRD patients in the years , surviving the first 90 days after ESRD initiation and followed from day 90. Adjusted for sex, race, primary diagnosis and Hispanic ethnicity. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.4 Hospitalization rates in pediatric patients (aged 0-19 years) (a) One-year adjusted all-cause hospitalization rates in pediatric patients by age

15 Vol 2, ESRD, Ch 715 Data Source: Special analyses, USRDS ESRD Database. Includes incident ESRD patients in the years , surviving the first 90 days after ESRD initiation and followed from day 90. Adjusted for sex, race, primary diagnosis and Hispanic ethnicity. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.4 Hospitalization rates in pediatric patients (aged 0-19 years) (b) One-year adjusted all-cause hospitalization rates in pediatric patients by modality

16 Vol 2, ESRD, Ch 716 Data Source: Special analyses, USRDS ESRD Database. Includes incident ESRD patients in the years , surviving the first 90 days after ESRD initiation and followed from day 90. Adjusted for sex, race, primary diagnosis and Hispanic ethnicity. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.5 Cardiovascular hospitalization rates in children (aged 0-19 years) (a) One-year adjusted cardiovascular hospitalization rates in pediatric patients by age

17 Vol 2, ESRD, Ch 717 Data Source: Special analyses, USRDS ESRD Database. Includes incident ESRD patients in the years , surviving the first 90 days after ESRD initiation and followed from day 90. Adjusted for sex, race, primary diagnosis and Hispanic ethnicity. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.5 Cardiovascular hospitalization rates in children (aged 0-19 years) (b) One-year adjusted cardiovascular hospitalization rates in pediatric patients by modality

18 Vol 2, ESRD, Ch 718 Data Source: Special analyses, USRDS ESRD Database. Includes incident ESRD patients in the years , surviving the first 90 days after ESRD initiation and followed from day 90. Adjusted for sex, race, primary diagnosis and Hispanic ethnicity. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.6 Infection hospitalization rates in children (aged 0-19 years) (a) One-year adjusted hospitalization rates for infection in pediatric patients by age

19 Vol 2, ESRD, Ch 719 Data Source: Special analyses, USRDS ESRD Database. Includes incident ESRD patients in the years , surviving the first 90 days after ESRD initiation and followed from day 90. Adjusted for sex, race, primary diagnosis and Hispanic ethnicity. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.6 Infection hospitalization rates in children (aged 0-19 years) (b) One-year adjusted hospitalization rates for infection in pediatric patients by modality

20 Vol 2, ESRD, Ch 720 Data Source: Reference tables F2, F14, I26. Probabilities for all-cause graft failure and return to dialysis or retransplant are adjusted for age, sex, race, primary diagnosis, and first versus subsequent transplant. All-cause graft failure includes retransplant, return to dialysis, and death. The death outcome is not censored at graft failure, and includes deaths that occur after retransplant or return to dialysis. Probabilities of death are adjusted for age, sex, race, and primary diagnosis. The reference population for all-cause graft failure and return to dialysis or repeat transplantation is all pediatric patients receiving a kidney alone transplant in The reference population for death is incident pediatric ESRD patients in vol 2 Figure 7.7 One year transplant outcomes by donor type (aged 0-19 years) (a) Outcomes: deceased donor transplants in pediatric patients, adjusted

21 Vol 2, ESRD, Ch 721 Data Source: Reference tables F8, F20, I32. Probabilities for all-cause graft failure and return to dialysis or retransplant are adjusted for age, sex, race, primary diagnosis, and first versus subsequent transplant. All-cause graft failure includes retransplant, return to dialysis, and death. The death outcome is not censored at graft failure, and includes deaths that occur after retransplant or return to dialysis. Probabilities of death are adjusted for age, sex, race, and primary diagnosis. The reference population for all-cause graft failure and return to dialysis or repeat transplantation is all pediatric patients receiving a kidney alone transplant in The reference population for death is incident pediatric ESRD patients in vol 2 Figure 7.7 One year transplant outcomes by donor type (aged 0-19 years) (b) Outcomes: live donor transplants in pediatric patients, adjusted

22 Vol 2, ESRD, Ch 722 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.8 Mortality rates in children with ESRD (aged 0-19 years) (a) One-year adjusted all-cause mortality rates in pediatric patients by age

23 Vol 2, ESRD, Ch 723 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.8 Mortality rates in children with ESRD (aged 0-19 years) (b) One-year adjusted all-cause mortality rates in pediatric patients by modality

24 Vol 2, ESRD, Ch 724 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.9 Cardiovascular mortality in children with ESRD (aged 0-19 years) (a) One-year adjusted all-cause cardiovascular mortality rates in pediatric patients by age

25 Vol 2, ESRD, Ch 725 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.9 Cardiovascular mortality in children with ESRD (aged 0-19 years) (b) One-year adjusted all-cause cardiovascular mortality rates in pediatric patients by modality

26 Vol 2, ESRD, Ch 726 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.10 Infection-related mortality in children with ESRD (aged 0-19 years) (a) One-year adjusted rates of mortality due to infection in pediatric patients by age

27 Vol 2, ESRD, Ch 727 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.10 Infection-related mortality in children with ESRD (aged 0-19 years) (b) One-year adjusted rates of mortality due to infection in pediatric patients by modality

28 Vol 2, ESRD, Ch 728 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.11 Pediatric ESRD patient survival by age and modality (aged 0-19 years) (a) Adjusted 5 year survival in pediatric patients from day 1 by age, years

29 Vol 2, ESRD, Ch 729 Data Source: Special analyses, USRDS ESRD Database. Incident dialysis and transplant patients defined at the onset of dialysis or the day of transplant without the 60-day rule; followed to December 31, Adjusted for age, sex, race, Hispanic ethnicity, and primary diagnosis. Ref: incident ESRD patients age 0-19, Abbreviations: HD, hemodialysis; PD, peritoneal dialysis; Tx, transplant. vol 2 Figure 7.11 Pediatric ESRD patient survival by age and modality (aged 0-19 years) (b) Adjusted 5 year survival in pediatric patients from day 1 by modality, years


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