1. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Risks of Progression of Retinopathy and Vision Loss Related to TightBlood Pressure Control in Type 2 Diabetes Mellitus: UKPDS 69 Arch Ophthalmol. 2004;122(11):1631-1640. doi:10.1001/archopht.122.11.1631 Relative risk (RR) of 5 or more microaneurysms(MAs) in those randomized to the tight (TBP) and less tight blood pressure(LTBP) control groups. A, Overall randomization. B, Those with no retinopathyat randomization. C, Those with any type of retinopathy at randomization.CI indicates confidence interval. Figure Legend:

2. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Risks of Progression of Retinopathy and Vision Loss Related to TightBlood Pressure Control in Type 2 Diabetes Mellitus: UKPDS 69 Arch Ophthalmol. 2004;122(11):1631-1640. doi:10.1001/archopht.122.11.1631 Relative risk (RR) of hard exudates(HEs) in those randomized to the tight (TBP) and less tight blood pressure(LTBP) control groups. A, Overall randomization. B, Those with no retinopathyat randomization. C, Those with any type of retinopathy at randomization.CI indicates confidence interval. Figure Legend:

3. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Risks of Progression of Retinopathy and Vision Loss Related to TightBlood Pressure Control in Type 2 Diabetes Mellitus: UKPDS 69 Arch Ophthalmol. 2004;122(11):1631-1640. doi:10.1001/archopht.122.11.1631 Relative risk (RR) of at least 1cotton-wool spot (CWS) in those randomized to the tight (TBP) and less tightblood pressure (LTBP) control groups. A, Overall randomization. B, Those withno retinopathy at randomization. C, Those with any type of retinopathy atrandomization. CI indicates confidence interval. Figure Legend:

4. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Risks of Progression of Retinopathy and Vision Loss Related to TightBlood Pressure Control in Type 2 Diabetes Mellitus: UKPDS 69 Arch Ophthalmol. 2004;122(11):1631-1640. doi:10.1001/archopht.122.11.1631 Relative risk (RR) of 2-step or worsedeterioration on the Early Treatment Diabetic Retinopathy Study (ETDRS) scalein those randomized to the tight (TBP) and less tight blood pressure (LTBP)control groups. A, Overall randomization. B, Those with no retinopathy atrandomization. C, Those with any type of retinopathy at randomization. CIindicates confidence interval. Figure Legend:

5. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Risks of Progression of Retinopathy and Vision Loss Related to TightBlood Pressure Control in Type 2 Diabetes Mellitus: UKPDS 69 Arch Ophthalmol. 2004;122(11):1631-1640. doi:10.1001/archopht.122.11.1631 Relative risk (RR) of retinal photocoagulationin those randomized to the tight (TBP) and less tight blood pressure (LTBP)control groups. CI indicates confidence interval. Figure Legend:

6. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Risks of Progression of Retinopathy and Vision Loss Related to TightBlood Pressure Control in Type 2 Diabetes Mellitus: UKPDS 69 Arch Ophthalmol. 2004;122(11):1631-1640. doi:10.1001/archopht.122.11.1631 Relative risk (RR) of 3 lines ormore of deterioration in either eye in those randomized to the tight (TBP)and less tight blood pressure (LTBP) control groups. CI indicates confidenceinterval. Figure Legend: