1. Date of download: 7/7/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults: A Systematic Review JAMA. 2009;301(22):2362-2375. doi:10.1001/jama.2009.815

2. Date of download: 7/7/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults: A Systematic Review JAMA. 2009;301(22):2362-2375. doi:10.1001/jama.2009.815 CI indicates confidence interval; VASSCSG, Veterans Administration Systemic Sepsis Cooperative Study Group. Size of the data markers indicates weight of the study. Figure Legend:

3. Date of download: 7/7/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults: A Systematic Review JAMA. 2009;301(22):2362-2375. doi:10.1001/jama.2009.815 CI indicates confidence interval. Size of the data markers indicates weight of the study. Figure Legend:

4. Date of download: 7/7/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults: A Systematic Review JAMA. 2009;301(22):2362-2375. doi:10.1001/jama.2009.815 Meta-regression analysis confirmed the positive interaction between dose/duration and survival benefit with corticosteroids, with lower risk ratios of death with (A) longer duration of treatment at a full dose (P =.01), (B) lower daily doses (P =.02), and (C) lower cumulative doses (P =.02). One study was excluded because it increased the I 2 value substantially in the set of early studies. Size of the data markers indicates weight of the study. Figure Legend:

5. Date of download: 7/7/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults: A Systematic Review JAMA. 2009;301(22):2362-2375. doi:10.1001/jama.2009.815 CI indicates confidence interval. Size of the data markers indicates weight of the study. Figure Legend: