1. Contractile Proteins Meghan Costello and Olivia Wallden

2. What is their function? -Contractile proteins are the force generators of muscle contraction -They are part of what makes up our muscle fibers, along with regulatory and structural proteins -The types of contractile proteins that are in muscle fibers are actin, which is part of thin filament, and myosin, which is part of thick filament

3. Role in Living Things

4. Myosin and Actin Cross Bridges

5. The non-globular shape of the contractile proteins is what allows them to function. Because they are are long strands of proteins, it is easier for them to slide back and forth - contracting. SHAPE

6. How proteins are made

7. Actin -Thin filament -Relatively small protein mmilvfwsny pyepvclash rnnmeasvpk ykkhlpqlgm qkemeqdvkr fgqaawatai prleklklml aqetlqlmra kelclnhkra eiqgkmedlp eqekninvvd elaiqfyeiq lelyevkfei lknkeilltt qldslerlik dei -If mutated or absent, the movement of the human would either be limited or none. Actin is essential to all muscle movement.

8. Organisms that have a similar protein to actin -Crab-eating macaque-WAS protein-like at 92% -Rhesus monkey-WASP associated with actin at 92% -(Predicted) Gorilla-WASP associated with actin at 93% -(Predicted) Chimpanzee-WASP associated with actin at 92% -(Predicted) Bolivian Squirrel Monkey- WASP associated with actin at 91%

9. Hypertrophic Cardiomyopathy

10. Symptoms -Chest pain -Dizziness -Fainting -Fatigue -Sensation of feeling the heart beat -Shortness of breath -Some see no symptoms

11. Resources http://class.fst.ohio-state.edu/FST822/lecturesab/Muscl.htm http://en.wikipedia.org/wiki/Actin#Actomyosin_filaments http://science.nasa.gov/science-news/science-at-nasa/2004/10dec_muscles/ https://docs.google.com/viewer?a=v&q=cache:xuhfM4By7gMJ:faculty.rcc.edu/o lin/docs/AMY2A/Lec18v2.ppt+&hl=en&gl=us&pid=bl&srcid=ADGEESiPuS7L dd- j31Ru4vghco_EThBpEquptacp258dT_MSLcYAAsHBuOxvOGT7qBS45xsW jREv6XCwisnod1yWqgXIDdL3IXpLjikBheRnv7Hftovrf9CEFWkts- SRzrEzuxjBWQ9B&sig=AHIEtbT4Tj4KPa0l7Wp1cgOCeDLWBaFCSQ http://www.sciencemuseum.org.uk/WhoAmI/FindOutMore/Yourbody/Whatdoyo urcellsdo/Howdocellsmakeproteins/Howareproteinsmade.aspx http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=83516 http://www.ncbi.nlm.nih.gov/protein/Q1A5X7.1 http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001243/