1. National Alliance for Medical Image Computing http://na-mic.org Volumetric Studies

2. National Alliance for Medical Image Computing http://na-mic.org Current Technology Image Acquisition: –1.5 Tesla GE scanner, 1 coronal SPGR, 1 axial Double Echo PD and T2w image. Rigid Registration: –Mutual Information Alignment. Brain Segmentation: –Expectation Minimization Segmentation in 4 tissue classes (White, Gray, CSF and Face). Manual Segmentation of Regions Of Interests. Statistical Analysis of the ROIs’ Volume.

3. National Alliance for Medical Image Computing http://na-mic.org 3D Slicer Segmentation –Level set –Fast Marching –EM Registration –Rigid –Non Linear 3D modeling Filtering Visualisation … http://www.slicer.org

4. National Alliance for Medical Image Computing http://na-mic.org Brain Segmentation W. Wells

5. National Alliance for Medical Image Computing http://na-mic.org Posterior Superior Temporal Gyrus (STG) Red = Left, Green= Right Amygdala. Yellow = Left, Light Blue = Right Hippocampus (Hipp.). Orange = Left, Dark Blue = Right Parahippocampal Gyrus (PHG). Dark Pink = Left, Purple = Right L. STG Hipp. L. Post. STG L. Ant. STG L. Hipp. L. Amygdala. PHG Hirayasu et al.

6. National Alliance for Medical Image Computing http://na-mic.org Volumetric Studies Findings Lateral Ventricles & CSF Enlargement. Parietal Volume Reduction. Temporal Lobe Volume Reductions –Amygdala-Hippocampal Complex, Parahippocampal Gyrus, & Superior Temporal Gyrus. Prefrontal Volume Reduction. Basal Ganglia (Caudate, Putamen, Globus Pallidus) increases and decreases.

7. National Alliance for Medical Image Computing http://na-mic.org Volumetric Studies

8. National Alliance for Medical Image Computing http://na-mic.org Shape: Global Measures J. Levitt and C.F. Westin

9. National Alliance for Medical Image Computing http://na-mic.org Shape: Surface Based Analysis H.J. Park and J. Levitt

10. National Alliance for Medical Image Computing http://na-mic.org Shape: Medial Representations J. Levitt and S. Bouix

11. National Alliance for Medical Image Computing http://na-mic.org Technical Challenges Image Quality and Acquisition Sequences. Multi Channel Atlas Based Segmentation. Multi Channel Image Registration. Model Based Segmentation. Shape Analysis. Cortical Thickness.