1. ir. Richard Bijlard Technogation - Invenios
True Room Temperature Bonding a novel process for the creation of health tech consumables ATB©
ir. Richard Bijlard
Technogation - Invenios
© Technogation – Invenios Dec 2014

2. Presentation Overview
Invenios Group
From Lab to POC
Challenges at creating advanced consumables
ATB (True Room Temperature Bonding)
Applications

3. Invenios Worldwide Langen (Hessen) Germany Eindhoven Netherlands
Santa Barbara,
California, USA

4. Health Tech Trends: from Lab to POC
Laboratory:
Large degree of freedom, versatile, high-end…
Stationary, expensive, specialist-use..

5. Lab-On-a-Chip… Select necessary functionalities for test
Shrink…in size …and in price!
possible to scale down?
absolutely necessary?
combination possible?
controllable -> pre-programmed!
inputs and outputs?
unambiguous interpretation of results!
reproducible?
mass-producible?
low cost?

6. Some necessary L-O-C functions
sample intake: capillary, active pump, …
process sequence control: valves,..
reagent availability: pre-loaded / externally connected
Heating/cooling
electrodes? fluid?
Measurement / readout
sample processing: separation?
chemical / electical / optical
on-chip, external display,…

7. And if you do it right, you get a solution that is:
Very portable! (true ‘Point-of-care’ solution)
Cheap (uses less reagents, sample..)
Fast
Easy-to-use
Safe …

8. Design & Construction of Consumables
Base material:
Paper: very cheap!
Plastic: cheap, easy to process
Glass: transparancy, low autofluorescence, thermally stable, resistant against solvents
Silicon: very mature semiconductor processes and tools available
Construction:
depends on material(s)
ideal situation: combine materials!
application dictates formfactor…. the smaller, the better ! (cheaper, portable,..!)
FOTURAN ® PSGC

9. Pre-loaded Consumables / Sensors
Problem
Need to have locally coated/functionalised structures…but chip needs to be hermetically closed
Glueing introduces toxicity
Anodic Bonding and Diffusion Bonding are NOT options:

10. Ambient (Room) Temperature Bonding (patented)
(->2) True Room temperature < 30o C
(->1) Two or more substrates (different CTEs possible!)
Thin film blocking layer on interface
No glue or high temperatures
Appropriate wavelength laser
Very locally created plasma, so bulk of the material stays at room temperature

11. Room Temperature Bonding - Characteristics
High bond strength > strength of the base material
Low temperatures, heat impacted zone < 1 µm of bond joint
Possible to create electrical leads in the same process step
Embed fluids or biomaterial/-coatings (Fibronectin, Poly-acrylamide gel, PFTE / Teflon,…)
Seals hermetically and in a vacuum, inert gas or even under water, if required
Scalable process, designed for operating in clean room production lines

12. What can you bond?
The following substrates can be bonded together in any combination:
Several types of Glasses
Quartz/Fuzed Silica
Sapphire
Silicon
Silicon Nitride
Silicon Oxide
Metals (Gold, Titanium,…)
Several plastics

13. Ambient Temperature (ATB©)
Properties Comparison
DIFFUSION
ANODIC
ADHESIVE
Ambient Temperature (ATB©)
High bond stability X
Simple, low-cost process ?
Surface Prep
Applicable for materials with mismatched CTE’s
Chemically resistant
Hermetically seals
High transparency
Temperature stable
Proprietary
Bonds in a vacuum

14. DNA sequencing Chips, Lab-on-a-chip
Dispensing
Cancer
Research
Chip
Electrofluidic lens

15. Application: Pressure Control Valve
Made of glass
Opening controlled by reference pressure
Wavefront guides prevent bubbles
Passive, implantable
Very durable

16. Pressure Control Valve

17. Conclusions
Trend towards Point Of Care requires small, smart and dedicated solutions
All materials have pros and cons…. advanced consumables combine best properties
ATB© enables connection of multiple materials on room temperature and does not harm biocoatings or – materials

18. Thank you for your attention!
Richard Bijlard Business Development Europe Technogation (an Invenios company)
phone:
© Technogation – Invenios Dec 2014