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Table of Contents – pages iv-v

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2 Table of Contents – pages iv-v
Unit 1: What is Biology? Unit 2: Ecology Unit 3: The Life of a Cell Unit 4: Genetics Unit 5: Change Through Time Unit 6: Viruses, Bacteria, Protists, and Fungi Unit 7: Plants Unit 8: Invertebrates Unit 9: Vertebrates Unit 10: The Human Body Table of Contents – pages iv-v

3 Table of Contents – pages iv-v
Unit 1: What is Biology? Chapter 1: Biology: The Study of Life Unit 2: Ecology Chapter 2: Principles of Ecology Chapter 3: Communities and Biomes Chapter 4: Population Biology Chapter 5: Biological Diversity and Conservation Unit 3: The Life of a Cell Chapter 6: The Chemistry of Life Chapter 7: A View of the Cell Chapter 8: Cellular Transport and the Cell Cycle Chapter 9: Energy in a Cell Table of Contents – pages iv-v

4 Table of Contents – pages iv-v
Unit 4: Genetics Chapter 10: Mendel and Meiosis Chapter 11: DNA and Genes Chapter 12: Patterns of Heredity and Human Genetics Chapter 13: Genetic Technology Unit 5: Change Through Time Chapter 14: The History of Life Chapter 15: The Theory of Evolution Chapter 16: Primate Evolution Chapter 17: Organizing Life’s Diversity Table of Contents – pages iv-v

5 Table of Contents – pages iv-v
Unit 6: Viruses, Bacteria, Protists, and Fungi Chapter 18: Viruses and Bacteria Chapter 19: Protists Chapter 20: Fungi Unit 7: Plants Chapter 21: What Is a Plant? Chapter 22: The Diversity of Plants Chapter 23: Plant Structure and Function Chapter 24: Reproduction in Plants Table of Contents – pages iv-v

6 Table of Contents – pages iv-v
Unit 8: Invertebrates Chapter 25: What Is an Animal? Chapter 26: Sponges, Cnidarians, Flatworms, and Roundworms Chapter 27: Mollusks and Segmented Worms Chapter 28: Arthropods Chapter 29: Echinoderms and Invertebrate Chordates Table of Contents – pages iv-v

7 Table of Contents – pages iv-v
Unit 9: Vertebrates Chapter 30: Fishes and Amphibians Chapter 31: Reptiles and Birds Chapter 32: Mammals Chapter 33: Animal Behavior Unit 10: The Human Body Chapter 34: Protection, Support, and Locomotion Chapter 35: The Digestive and Endocrine Systems Chapter 36: The Nervous System Chapter 37: Respiration, Circulation, and Excretion Chapter 38: Reproduction and Development Chapter 39: Immunity from Disease Table of Contents – pages iv-v

8 Genetics Mendel and Meiosis DNA and Genes
Patterns of Heredity and Human Genetics Genetic Technology Unit Overview – pages

9 Chapter Contents – page viii
Chapter 11 DNA and Genes 11.1: DNA: The Molecule of Heredity 11.1: Section Check 11.2: From DNA to Protein 11.2: Section Check 11.3: Genetic Changes 11.3: Section Check Chapter 11 Summary Chapter 11 Assessment Chapter Contents – page viii

10 You will relate the structure of DNA to its function.
What You’ll Learn You will relate the structure of DNA to its function. You will explain the role of DNA in protein production. You will distinguish among different types of mutations. Chapter Intro-page 280

11 11.1 Section Objectives – page 281
Analyze the structure of DNA Determine how the structure of DNA enables it to reproduce itself accurately. 11.1 Section Objectives – page 281

12 Section 11.1 Summary – pages 281 - 287
What is DNA? Although the environment influences how an organism develops, the genetic information that is held in the molecules of DNA ultimately determines an organism’s traits. DNA achieves its control by determining the structure of proteins. Section 11.1 Summary – pages

13 Section 11.1 Summary – pages 281 - 287
What is DNA? All actions, such as eating, running, and even thinking, depend on proteins called enzymes. Enzymes are critical for an organism’s function because they control the chemical reactions needed for life. Within the structure of DNA is the information for life—the complete instructions for manufacturing all the proteins for an organism. Section 11.1 Summary – pages

14 Section 11.1 Summary – pages 281 - 287
DNA as the genetic material In 1952 Alfred Hershey and Martha Chase performed an experiment using radioactively labeled viruses that infect bacteria. These viruses were made of only protein and DNA. Section 11.1 Summary – pages

15 Section 11.1 Summary – pages 281 - 287
DNA as the genetic material Hershey and Chase labeled the virus DNA with a radioactive isotope and the virus protein with a different isotope. By following the infection of bacterial cells by the labeled viruses, they demonstrated that DNA, rather than protein, entered the cells and caused the bacteria to produce new viruses. Section 11.1 Summary – pages

16 Section 11.1 Summary – pages 281 - 287
The structure of nucleotides DNA is a polymer made of repeating subunits called nucleotides. Nitrogenous base Phosphate group Sugar (deoxyribose) Nucleotides have three parts: a simple sugar, a phosphate group, and a nitrogenous base. Section 11.1 Summary – pages

17 Section 11.1 Summary – pages 281 - 287
The structure of nucleotides The simple sugar in DNA, called deoxyribose (dee ahk sih RI bos), gives DNA its name—deoxyribonucleic acid. The phosphate group is composed of one atom of phosphorus surrounded by four oxygen atoms. Section 11.1 Summary – pages

18 Section 11.1 Summary – pages 281 - 287
The structure of nucleotides A nitrogenous base is a carbon ring structure that contains one or more atoms of nitrogen. In DNA, there are four possible nitrogenous bases: adenine (A), guanine (G), cytosine (C), and thymine (T). Adenine (A) Guanine (G) Cytosine (C) Thymine (T) Section 11.1 Summary – pages

19 Section 11.1 Summary – pages 281 - 287
The structure of nucleotides Thus, in DNA there are four possible nucleotides, each containing one of these four bases. Section 11.1 Summary – pages

20 Section 11.1 Summary – pages 281 - 287
The structure of nucleotides Nucleotides join together to form long chains, with the phosphate group of one nucleotide bonding to the deoxyribose sugar of an adjacent nucleotide. The phosphate groups and deoxyribose molecules form the backbone of the chain, and the nitrogenous bases stick out like the teeth of a zipper. Section 11.1 Summary – pages

21 Section 11.1 Summary – pages 281 - 287
The structure of nucleotides In DNA, the amount of adenine is always equal to the amount of thymine, and the amount of guanine is always equal to the amount of cytosine. Section 11.1 Summary – pages

22 Section 11.1 Summary – pages 281 - 287
The structure of DNA In 1953, Watson and Crick proposed that DNA is made of two chains of nucleotides held together by nitrogenous bases. Watson and Crick also proposed that DNA is shaped like a long zipper that is twisted into a coil like a spring. Because DNA is composed of two strands twisted together, its shape is called double helix. Section 11.1 Summary – pages

23 Section 11.1 Summary – pages 281 - 287
The importance of nucleotide sequences The sequence of nucleotides forms the unique genetic information of an organism. The closer the relationship is between two organisms, the more similar their DNA nucleotide sequences will be. Chromosome Section 11.1 Summary – pages

24 Section 11.1 Summary – pages 281 - 287
The importance of nucleotide sequences Scientists use nucleotide sequences to determine evolutionary relationships among organisms, to determine whether two people are related, and to identify bodies of crime victims. Section 11.1 Summary – pages

25 Section 11.1 Summary – pages 281 - 287
Replication of DNA Before a cell can divide by mitosis or meiosis, it must first make a copy of its chromosomes. The DNA in the chromosomes is copied in a process called DNA replication. Without DNA replication, new cells would have only half the DNA of their parents. Section 11.1 Summary – pages

26 Section 11.1 Summary – pages 281 - 287
DNA Replication Replication of DNA Replication Section 11.1 Summary – pages

27 Section 11.1 Summary – pages 281 - 287
Replication of DNA Click this image to view movie Section 11.1 Summary – pages

28 Section 11.1 Summary – pages 281 - 287
Copying DNA DNA is copied during interphase prior to mitosis and meiosis. It is important that the new copies are exactly like the original molecules. Section 11.1 Summary – pages

29 Section 11.1 Summary – pages 281 - 287
Copying DNA New DNA molecule Original DNA Strand Free Nucleotides New DNA molecule New DNA Strand Original DNA Strand Original DNA Section 11.1 Summary – pages

30 Question 1 What importance did the experiment performed by Alfred Hershey and Martha Chase have in determining what genetic material was? Answer Many scientists believed protein was the genetic material. However, an experiment using radioactively labeled viruses allowed Hershey and Chase to provide convincing evidence that DNA is the genetic material. Section 1 Check

31 Question 2 Which of the following is NOT a component of DNA?
A. simple sugars B. phosphate groups C. nitrogenous bases D. proteins The answer is D. Section 1 Check

32 Question 3 Which of the following correctly comprises a complimentary base pair? A. adenine – thymine B. thymine – guanine C. guanine – adenine D. cytosine – thymine The answer is A. Section 1 Check

33 Section 2 Objectives – page 288
Relate the concept of the gene to the sequence of nucleotides in DNA. Sequence the steps involved in protein synthesis. Section 2 Objectives – page 288

34 Section 11.2 Summary – pages 288 - 295
Genes and Proteins The sequence of nucleotides in DNA contain information. This information is put to work through the production of proteins. Proteins fold into complex, three dimensional shapes to become key cell structures and regulators of cell functions. Section 11.2 Summary – pages

35 Section 11.2 Summary – pages 288 - 295
Genes and Proteins Some proteins become important structures, such as the filaments in muscle tissue. Other proteins, such as enzymes, control chemical reactions that perform key life functions—breaking down glucose molecules in cellular respiration, digesting food, or making spindle fibers during mitosis. Section 11.2 Summary – pages

36 Section 11.2 Summary – page 288 - 295
Genes and Proteins In fact, enzymes control all the chemical reactions of an organism. Thus, by encoding the instructions for making proteins, DNA controls cells. Section 11.2 Summary – page

37 Section 11.2 Summary – page 2888- 295
Genes and Proteins You learned earlier that proteins are polymers of amino acids. The sequence of nucleotides in each gene contains information for assembling the string of amino acids that make up a single protein. Section 11.2 Summary – page

38 Section 11.2 Summary – pages 288 - 295
RNA RNA like DNA, is a nucleic acid. RNA structure differs from DNA structure in three ways. First, RNA is single stranded—it looks like one-half of a zipper —whereas DNA is double stranded. Section 11.2 Summary – pages

39 Section 11.2 Summary – pages 288 - 295
RNA Ribose The sugar in RNA is ribose; DNA’s sugar is deoxyribose. Section 11.2 Summary – pages

40 Section 11.2 Summary – pages 288 - 295
RNA Both DNA and RNA contain four nitrogenous bases, but rather than thymine, RNA contains a similar base called uracil (U). Uracil forms a base pair with adenine in RNA, just as thymine does in DNA. Uracil Hydrogen bonds Adenine Section 11.2 Summary – pages

41 Section 11.2 Summary – pages 288 - 295
RNA DNA provides workers with the instructions for making the proteins, and workers build the proteins. The workers for protein synthesis are RNA molecules. Section 11.2 Summary – pages

42 Section 11.2 Summary – pages 288 - 295
RNA DNA provides workers with the instructions for making the proteins, and workers build the proteins. The workers for protein synthesis are RNA molecules. They take from DNA the instructions on how the protein should be assembled, then—amino acid by amino acid—they assemble the protein. Section 11.2 Summary – pages

43 Section 11.2 Summary – pages 288 - 295
RNA There are three types of RNA that help build proteins. Messenger RNA (mRNA), brings instructions from DNA in the nucleus to the cell’s factory floor, the cytoplasm. On the factory floor, mRNA moves to the assembly line, a ribosome. Section 11.2 Summary – pages

44 Section 11.2 Summary – pages 288 - 295
RNA The ribosome, made of ribosomal RNA (rRNA), binds to the mRNA and uses the instructions to assemble the amino acids in the correct order. Section 11.2 Summary – pages

45 Section 11.2 Summary – pages 288 - 295
RNA Transfer RNA (tRNA) is the supplier. Transfer RNA delivers amino acids to the ribosome to be assembled into a protein. Click image to view movie Section 11.2 Summary – pages

46 Section 11.2 Summary – pages 288 - 295
Transcription In the nucleus, enzymes make an RNA copy of a portion of a DNA strand in a process called transcription. Section 11.2 Summary – pages

47 Section 11.2 Summary – pages 288 - 295
Transcription Section 11.2 Summary – pages

48 Section 11.2 Summary – pages 288 - 295
Transcription The main difference between transcription and DNA replication is that transcription results in the formation of one single-stranded RNA molecule rather than a double-stranded DNA molecule. Section 11.2 Summary – pages

49 Section 11.2 Summary – pages 288 - 295
RNA Processing Not all the nucleotides in the DNA of eukaryotic cells carry instructions—or code—for making proteins. Genes usually contain many long noncoding nucleotide sequences, called introns, that are scattered among the coding sequences. Section 11.2 Summary – pages

50 Section 11.2 Summary – pages 288 - 295
RNA Processing Regions that contain information are called exons because they are expressed. When mRNA is transcribed from DNA, both introns and exons are copied. The introns must be removed from the mRNA before it can function to make a protein. Section 11.2 Summary – pages

51 Section 11.2 Summary – pages 288 - 295
RNA Processing Enzymes in the nucleus cut out the intron segments and paste the mRNA back together. The mRNA then leaves the nucleus and travels to the ribosome. Section 11.2 Summary – pages

52 Section 11.2 Summary – pages 288 - 295
The Genetic Code The nucleotide sequence transcribed from DNA to a strand of messenger RNA acts as a genetic message, the complete information for the building of a protein. As you know, proteins contain chains of amino acids. You could say that the language of proteins uses an alphabet of amino acids. Section 11.2 Summary – pages

53 The Genetic Code A code is needed to convert the language of mRNA into the language of proteins. Biochemists began to crack the genetic code when they discovered that a group of three nitrogenous bases in mRNA code for one amino acid. Each group is known as a codon.

54 Section 11.2 Summary – pages 288 - 295
The Genetic Code Sixty-four combinations are possible when a sequence of three bases is used; thus, 64 different mRNA codons are in the genetic code. Section 11.2 Summary – pages

55 Section 11.2 Summary – pages 288 - 295
The Genetic Code The Messenger RNA Genetic Code First Letter Third Letter Second Letter U C A G U Phenylalanine (UUU) Serine (UCU) Tyrosine (UAU) Cysteine (UGU) U Phenylalanine (UUC) Serine (UCC) Tyrosine (UAC) Cysteine (UGC) C Leucine (UUA) Serine (UCA) Stop (UAA) Stop (UGA) A Leucine (UUG) Serine (UCG) Stop (UAG) Tryptophan (UGG) G C Leucine (CUU) Proline (CCU) Histadine (CAU) Arginine (CGU) U Leucine (CUC) Proline (CCC) Histadine (CAC) Arginine (CGC) C Leucine (CUA) Proline (CCA) Glutamine (CAA) Arginine (CGA) A Leucine (CUG) Proline (CCG) Glutamine (CAG) Arginine (CGG) G A Isoleucine (AUU) Threonine (ACU) Asparagine (AAU) Serine (AGU) U Isoleucine (AUC) Threonine (ACC) Asparagine (AAC) Serine (AGC) C Isoleucine (AUA) Threonine (ACA) Lysine (AAA) Arginine (AGA) A Methionine;Start (AUG) Threonine (ACG) Lysine (AAG) Arginine (AGG) G G Valine (GUU) Alanine (GCU) Aspartate (GAU) Glycine (GGU) U Valine (GUC) Alanine (GCC) Aspartate (GAC) Glycine (GGC) Glycine (GGC) C Valine (GUA) Alanine (GCA) Glutamate (GAA) Glycine (GGA) A Valine (GUG) Alanine (GCG) Glutamate (GAG) Glycine (GGG) G Section 11.2 Summary – pages

56 Section 11.2 Summary – pages 288 - 295
The Genetic Code Some codons do not code for amino acids; they provide instructions for making the protein. More than one codon can code for the same amino acid. However, for any one codon, there can be only one amino acid. Section 11.2 Summary – pages

57 Section 11.2 Summary – pages 288 - 295
The Genetic Code All organisms use the same genetic code. This provides evidence that all life on Earth evolved from a common origin. Section 11.2 Summary – pages

58 Section 11.2 Summary – pages 288 - 295
Translation: From mRNA to Protein The process of converting the information in a sequence of nitrogenous bases in mRNA into a sequence of amino acids in protein is known as translation. Translation takes place at the ribosomes in the cytoplasm. In prokaryotic cells, which have no nucleus, the mRNA is made in the cytoplasm. Section 11.2 Summary – pages

59 Section 11.2 Summary – pages 288 - 295
Translation: From mRNA to Protein In eukaryotic cells, mRNA is made in the nucleus and travels to the cytoplasm. In cytoplasm, a ribosome attaches to the strand of mRNA like a clothespin clamped onto a clothesline. Section 11.2 Summary – pages

60 Section 11.2 Summary – pages 288 - 295
The role of transfer RNA For proteins to be built, the 20 different amino acids dissolved in the cytoplasm must be brought to the ribosomes. This is the role of transfer RNA. Section 11.2 Summary – pages

61 Section 11.2 Summary – pages 288 - 295
The role of transfer RNA Amino acid Each tRNA molecule attaches to only one type of amino acid. Chain of RNA nucleotides Transfer RNA molecule Anticondon Section 11.2 Summary – pages

62 Section 11.2 Summary – pages 288 - 295
Translation Section 11.2 Summary – pages

63 Section 11.2 Summary – pages 288 - 295
The role of transfer RNA Ribosome mRNA codon Section 11.2 Summary – pages

64 Section 11.2 Summary – pages 288 - 295
The role of transfer RNA Usually, the first codon on mRNA is AUG, which codes for the amino acid methionine. AUG signals the start of protein synthesis. When this signal is given, the ribosome slides along the mRNA to the next codon. Section 11.2 Summary – pages

65 Section 11.2 Summary – pages 288 - 295
The role of transfer RNA Methionine tRNA anticodon Section 11.2 Summary – pages

66 Section 11.2 Summary – pages 288 - 295
The role of transfer RNA A new tRNA molecule carrying an amino acid pairs with the second mRNA codon. Alanine Section 11.2 Summary – pages

67 Section 11.2 Summary – pages 288- 295
The role of transfer RNA The amino acids are joined when a peptide bond is formed between them. Methionine Alanine Peptide bond Section 11.2 Summary – pages

68 Section 11.2 Summary – pages 288 - 295
The role of transfer RNA A chain of amino acids is formed until the stop codon is reached on the mRNA strand. Stop codon Section 11.2 Summary – pages

69 Question 1 What are the three chemical differences between RNA and DNA? Answer RNA consists of a single strand of nucleotides whereas DNA is a double strand. RNA contains ribose as its sugar and DNA contains deoxyribose as its sugar. Uracil in RNA replaces thymine in DNA as the nitrogenous base. Section 2 Check

70 Question 2 Answer What is the role of rRNA in protein synthesis?
Ribosomal RNA binds to messenger RNA and assembles the amino acids in the order needed for the protein to be synthesized. Section 2 Check

71 Question 3 Which regions of the mRNA travel to the ribosome; introns, exons, or both? Answer Only exons, which contain coding information, travel to the ribosome. Introns, noncoding nucleotide sequences, do not travel to the ribosome. Section 2 Check

72 Question 4 Answer What is an anticodon, and what does it represent?
An anticodon is a sequence of three nucleotides on the tRNA molecule that binds to a codon of the mRNA strand. Section 2 Check

73 11.3 Section Objectives – page 296
Categorize the different kinds of mutations that can occur in DNA. Compare the effects of different kinds of mutations on cells and organisms. 11.3 Section Objectives – page 296

74 11.3 Section Summary 6.3 – pages 296 - 301
Mutations Organisms have evolved many ways to protect their DNA from changes. In spite of these mechanisms, however, changes in the DNA occasionally do occur. Any change in DNA sequence is called a mutation. Mutations can be caused by errors in replication, transcription, cell division, or by external agents. 11.3 Section Summary 6.3 – pages

75 11.3 Section Summary 6.3 – pages 296 - 301
Mutations in reproductive cells Mutations can affect the reproductive cells of an organism by changing the sequence of nucleotides within a gene in a sperm or an egg cell. If this cell takes part in fertilization, the altered gene would become part of the genetic makeup of the offspring. 11.3 Section Summary 6.3 – pages

76 11.3 Section Summary 6.3 – pages 296 - 301
Mutations in reproductive cells The mutation may produce a new trait or it may result in a protein that does not work correctly. Sometimes, the mutation results in a protein that is nonfunctional, and the embryo may not survive. In some rare cases a gene mutation may have positive effects. 11.3 Section Summary 6.3 – pages

77 11.3 Section Summary 6.3 – pages 296 - 301
Mutations in body cells What happens if powerful radiation, such as gamma radiation, hits the DNA of a nonreproductive cell, a cell of the body such as in skin, muscle, or bone? If the cell’s DNA is changed, this mutation would not be passed on to offspring. However, the mutation may cause problems for the individual. 11.3 Section Summary 6.3 – pages

78 11.3 Section Summary 6.3 – pages 296 - 301
Mutations in body cells Damage to a gene may impair the function of the cell. When that cell divides, the new cells also will have the same mutation. Some mutations of DNA in body cells affect genes that control cell division. This can result in the cells growing and dividing rapidly, producing cancer. 11.3 Section Summary 6.3 – pages

79 11.3 Section Summary 6.3 – pages 296 - 301
The effects of point mutations A point mutation is a change in a single base pair in DNA. A change in a single nitrogenous base can change the entire structure of a protein because a change in a single amino acid can affect the shape of the protein. 11.3 Section Summary 6.3 – pages

80 11.3 Section Summary 6.3 – pages 296 - 301
The effects of point mutations mRNA Normal Protein Stop Replace G with A Point mutation mRNA Protein Stop 11.3 Section Summary 6.3 – pages

81 11.3 Section Summary 6.3 – pages 296 - 301
Frameshift mutations What would happen if a single base were lost from a DNA strand? This new sequence with the deleted base would be transcribed into mRNA. But then, the mRNA would be out of position by one base. As a result, every codon after the deleted base would be different. 11.3 Section Summary 6.3 – pages

82 11.3 Section Summary 6.3 – pages 296 - 301
Frameshift mutations Deletion of U Frameshift mutation mRNA Protein 11.3 Section Summary 6.3 – pages

83 11.3 Section Summary 6.3 – pages 296 - 301
Frameshift mutations This mutation would cause nearly every amino acid in the protein after the deletion to be changed. A mutation in which a single base is added or deleted from DNA is called a frameshift mutation because it shifts the reading of codons by one base. 11.3 Section Summary 6.3 – pages

84 11.3 Section Summary 6.3 – pages 296 - 301
Chromosomal Alterations Changes may occur in chromosomes as well as in genes. Alterations to chromosomes may occur in a variety of ways. Structural changes in chromosomes are called chromosomal mutations. 11.3 Section Summary 6.3 – pages

85 11.3 Section Summary 6.3 – pages 296 - 301
Chromosomal Alterations Chromosomal mutations occur in all living organisms, but they are especially common in plants. Few chromosomal mutations are passed on to the next generation because the zygote usually dies. 11.3 Section Summary 6.3 – pages

86 11.3 Section Summary 6.3 – pages 296 - 301
Chromosomal Alterations In cases where the zygote lives and develops, the mature organism is often sterile and thus incapable of producing offspring. When a part of a chromosome is left out, a deletion occurs. A B C D E F G H A B C E F G H Deletion 11.3 Section Summary 6.3 – pages

87 11.3 Section Summary 6.3 – pages 296 - 301
Chromosomal Alterations When part of a chromatid breaks off and attaches to its sister chromatid, an insertion occurs. The result is a duplication of genes on the same chromosome. A B C D E F G H A B C B C D E F G H Insertion 11.3 Section Summary 6.3 – pages

88 11.3 Section Summary 6.3 – pages 296 - 301
Chromosomal Alterations When part of a chromosome breaks off and reattaches backwards, an inversion occurs. A B C D E F G H A D C B E F G H Inversion 11.3 Section Summary 6.3 – pages

89 11.3 Section Summary 6.3 – pages 296 - 301
Chromosomal Alterations When part of one chromosome breaks off and is added to a different chromosome, a translocation occurs. A B C D E F G H W X A B C D E F G H W X Y Z Y Z Translocation 11.3 Section Summary 6.3 – pages

90 11.3 Section Summary 6.3 – pages 296 - 301
Causes of Mutations Some mutations seem to just happen, perhaps as a mistake in base pairing during DNA replication. These mutations are said to be spontaneous. However, many mutations are caused by factors in the environment. 11.3 Section Summary 6.3 – pages

91 11.3 Section Summary 6.3 – pages 296 - 301
Causes of Mutations Any agent that can cause a change in DNA is called a mutagen. Mutagens include radiation, chemicals, and even high temperatures. Forms of radiation, such as X rays, cosmic rays, ultraviolet light, and nuclear radiation, are dangerous mutagens because the energy they contain can damage or break apart DNA. 11.3 Section Summary 6.3 – pages

92 11.3 Section Summary 6.3 – pages 296 - 301
Causes of Mutations The breaking and reforming of a double-stranded DNA molecule can result in deletions. Chemical mutagens include dioxins, asbestos, benzene, and formaldehyde, substances that are commonly found in buildings and in the environment. Chemical mutagens usually cause substitution mutations. 11.3 Section Summary 6.3 – pages

93 11.3 Section Summary 6.3 – pages 296 - 301
Repairing DNA Repair mechanisms that fix mutations in cells have evolved. Enzymes proofread the DNA and replace incorrect nucleotides with correct nucleotides. These repair mechanisms work extremely well, but they are not perfect. The greater the exposure to a mutagen such as UV light, the more likely is the chance that a mistake will not be corrected. 11.3 Section Summary 6.3 – pages

94 Question 1 Any change in DNA sequences is called a _______.
A. replication B. mutation C. transcription D. translation The answer is B. Section 3 Check

95 Question 2 Which is more serious, a point mutation or a frameshift mutation? Why? Answer A frameshift mutation is more serious than a point mutation because it disrupts more codons than a point mutation. Section 3 Check

96 Question 3 Why are chromosomal mutations rarely passed on to the next generation? Answer Few chromosomal changes are passed on to the next generation because the zygote usually dies. If the zygote survives, it is often sterile and incapable of producing offspring. Section 3 Check

97 DNA: The Molecule of Heredity
Alfred Hershey and Martha Chase demonstrated that DNA is the genetic material. Because adenine can pair only with thymine, and guanine can pair only with cytosine, DNA can replicate itself with great accuracy. Chapter Summary – 11.1

98 DNA: The Molecule of Heredity
DNA, the genetic material of organisms, is composed of four kinds of nucleotides. A DNA molecule consists of two strands of nucleotides with sugars and phosphates on the outside and bases paired by hydrogen bonding on the inside. The paired strands form a twisted-zipper shape called a double helix. Chapter Summary – 11.1

99 From DNA to Protein Genes are small sections of DNA. Most sequences of three bases in the DNA of a gene code for a single amino acid in a protein. Messenger RNA is made in a process called transcription. The order of nucleotides in DNA determines the order of nucleotides in messenger RNA. Chapter Summary – 11.2

100 From DNA to Protein Translation is a process through which the order of bases in messenger RNA codes for the order of amino acids in a protein. Chapter Summary – 11.2

101 Genetic Changes A mutation is a change in the base sequence of DNA. Mutations may affect only one gene, or they may affect whole chromosomes. Mutations in eggs or sperm affect future generations by producing offspring with new characteristics. Mutations in body cells affect only the individual and may result in cancer. Chapter Summary – 11.3

102 Question 1 How does DNA control the structures and functions of a cell? Answer DNA determines the structure of proteins. Some proteins become important cell structures. Other proteins, such as enzymes, control chemical reactions that perform key life functions. Chapter Assessment

103 Question 2 The process through which the order of bases in messenger RNA codes for the order of amino acids in a protein is: A. transcription B. translation C. replication D. point mutation The answer is B. Chapter Assessment

104 Question 3 Why would scientists use nucleotide sequences to identify bodies of crime victims? Answer In comparing nucleotide sequences in the DNA of a crime victim with nucleotide sequences from a possible close relative of the crime victim, scientists can determine if the two are related. Chapter Assessment

105 Question 4 What happens when a stop codon is reached during translation? Answer When a stop codon is reached, translation ends and the amino acid strand is released from the ribosome. Chapter Assessment

106 Question 5 A ________ bond forms between adjacent amino acids during translation. A. nucleotide B. phosphate C. hydrogen D. peptide The answer is D. Chapter Assessment

107 Question 6 What is the difference between a purine and a pyrimidine? Answer A purine is a double-ringed nitrogenous base. A pyrimidine is a single-ringed nitrogenous base. Chapter Assessment

108 Question 7 Answer Why is DNA replication important to cell division?
Without DNA replication, new cells would have only half the DNA of their parents. Species could not survive and individuals could not grow or reproduce successfully. Chapter Assessment

109 Question 8 At the beginning and end of replication, which of the following are instrumental in breaking and bonding the hydrogen bonds between bases? A. pyrimidines B. purines C. nucleotides D. enzymes The answer is D. Chapter Assessment

110 Question 9 Answer What is the role of mRNA in protein synthesis?
The messenger RNA acts as a genetic message, providing the complete information, in sequences of codons, for the building of a protein. Chapter Assessment

111 Question 10 The DNA sequences of a parrot _________.
A. are more similar to those of a clam than a robin B. are more similar to a fern than a dog C. are exactly the same as those of a human D. contain exactly the same nucleotides as those of a beetle The answer is D. Chapter Assessment

112 To advance to the next item or next page click on any of the following keys: mouse, space bar, enter, down or forward arrow. Click on this icon to return to the table of contents Click on this icon to return to the previous slide Click on this icon to move to the next slide Click on this icon to open the resources file.

113 End of Chapter 11 Show


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