1. Suppl. Figure 1 APP23 + X Terc +/- Terc +/-, APP23 + X Terc +/- G1Terc -/-, APP23 + X G1Terc -/- G2Terc -/-, APP23 + X G2Terc -/- G3Terc -/-, APP23 + and G3Terc -/-, APP23 -

2. Suppl. Figure 2 A B C BACE-1 GAPDH Terc +/+, APP23 + G3Terc -/-, APP23 + Presenilin-2 GAPDH Terc +/+, APP23 + G3Terc -/-, APP23 + Presenilin-1 βActin Terc +/+, APP23 + G3Terc -/-, APP23 + Terc +/+, APP23 + βActin APP G3Terc -/-, APP23 + D E 5 10 15 20 25 APP Expression (Relative to GAPDH) G3Terc -/- APP23 + Terc +/+ APP23 + P=0.5784

3. Suppl. Figure 3 A B CD Terc +/+, APP23 - G3Terc -/-, APP23 - Terc +/+, APP23 + G3Terc -/-, APP23 + C AB D

4. B DAPIIba1-FITC BrdU-Cy3Overlay Suppl. Figure 4 10 20 30 40 BrdU/Iba-1 Positive Cells /Vision Field (Cortex) G3Terc -/- APP23 - Terc +/+ APP23 - P=0.5205 A

5. Suppl. Figure 5 A C B Iba-1 Positive Cells /Unit Plaque Area G3Terc -/- APP23 + Terc +/+ APP23 + 0 2 4 6 G3Terc -/- APP23 + Terc +/+ APP23 + 0 1 2 3 mRNA Expression (Relative to GAPDH) G3Terc -/-, APP23 - Terc +/+, APP23 - TGF-beta 0.0 0.5 1.0 1.5 IL1-beta 0.0 0.5 1.0 1.5 CXCL10 0.0 1.0 2.0 3.0 TNF-alpha 0.0 2.0 4.0 6.0 IL6 0.0 2.0 4.0 6.0 CCL5 CCL2 0.0 1.0 2.0 3.0 0.0 1.0 2.0 3.0 MHCII 0.0 0.5 1.0 1.5 MHCII mRNA Expression (Relative to GAPDH) P=0.9241 P=0.5727

6. Suppl. Figure 6 5 10 15 20 25 Number of Astrocytes at Plaques Vicinity G3Terc -/- APP23 + Terc +/+ APP23 + P=0.7365

7. Suppl. Table 1 Primer NameSequence Il1-beta For 5´-TGT AAT GAA AGA CGG CAC ACC-3´ Il1-beta Rev 5´-TCT TCT TTG GGT ATT GCT TGG-3´ Il6 For 5'-GTC ACC AAA CTG GAT ATA ATC AGG-3´ Il6 Rev 5´-CCA GGT AGC TAT GGT ACT CCA GAA-3´ CCL2 For 5´-TTC AGT CTG GTA ACA TGA CGG-3´ CCL2 Rev 5´-GGT GCG TTG AGT CTG GCA TAA-3´ CCL5 For 5´-ACA CAC TTG GCG GTT CCT TC-3´ CCL5 Rev 5´-TGC TCC AAT CTT GCA GTC GT-3´ TGF-beta For 5´-TGG AGC TGG TGA AAC GGA AG-3´ TGF-beta Rev 5´-ACA GGA TCT GGC CAC GGA T-3´ TNF-alpha For 5´-TGC CTA TGT CCT CTT C-3´ TNF-alpha Rev 5´-GAG GCC ATT TAC TTC T-3´ CXCL10 For 5´-GCT CGC AGG GAT GAT TTC AA-3´ CXCL10 Rev 5´-GGG CCA GTG AGA ATG AGG G-3´ MHCII For 5'-CCA GTA ACC CCT CCT CAC ATC-3´ MHCII Rev 5'-TCC TAC AGG CTG CTG ACA AG-3´