1. Printing: Your printer might not print the same way our printers do, so make sure to try a couple of test prints. If things aren’t aligning quite right, experiment with the Scale to Fit Paper setting. It’s located in the Print dialog – just click Full Page Slides to get to it. And did you notice we made fold marks for you? They are really light, but if you don’t like them showing on your brochure, click View, Slide Master, and delete them before you print. Customizing the Content: If you need more placeholders for titles, subtitles or body text, just make a copy of what you need and drag it into place. PowerPoint’s Smart Guides will help you align it with everything else. Additional Information: Amy Albritton Honor’s Anatomy and Physiology Prattville High School April 4, 2014 amy.b.albritton@acboe.net (adrenoleukodystrophy) Lorenzo’s Oil Refinery “a bootleg company” ALD http://ghr.nlm.nih.gov/search?query http://omim.org/entry/300100 http://www.childrenscancer.org behavioral changes poor memory and poor school performance visual loss, seizures, deafness difficulties with speechswallowing and coordination Fecal and urinary incontinence Cerebral demyelination and inflammation SYMPTOMS

2. Printing: Your printer might not print the same way our printers do, so make sure to try a couple of test prints. If things aren’t aligning quite right, experiment with the Scale to Fit Paper setting. It’s located in the Print dialog – just click Full Page Slides to get to it. And did you notice we made fold marks for you? They are really light, but if you don’t like them showing on your brochure, click View, Slide Master, and delete them before you print. Customizing the Content: If you need more placeholders for titles, subtitles or body text, just make a copy of what you need and drag it into place. PowerPoint’s Smart Guides will help you align it with everything else. affects all ethnic groups most common inherited leukodystrophy minimum incidence ranging from 1:42,000 untreated, ALD will cause death in three to five years progression can be stabilized no cure yet Our Research Treatment Plan: What does it do to the CNS? mutation in the ABCD1 gene What causes ALD? X-linked recessive genetic disorder that affects males. ‘adreno’ refers to the adrenal glands; ‘leuko’ refers to the white matter of the brain, and ‘dystrophy’ means abnormal growth or development. A peroxisomal disease damages the myelin sheath on neurons no production of protein that helps break down fatty acids accumulation of the saturated very long chain fatty acids in all body tissues. What is Adrenoleukodystrophy? bone marrow transplant intravenous mesenchymal stem cells during the period before the transplant high-dose antioxidant therapy provide families with emotional support, networking opportunities, and other kinds of assistance Adrenal steroid replacement therapy Hematopoietic stem cell transplantation gene therapy allogeneic hematopoietic stem cell transplantation (HSCT) “When we found out that all three of our boys, Owen, Dylan and Jacob, had it, we were devastated.” Darlene, mother of the boys