1. SYNESTHESIA

2. WHAT IS SYNESTHESIA? The word synesthesia comes from two Greek words, syn (together) and aisthesis (perception). Therefore, synesthesia literally means "joined perception."

3. WHAT IS SYNESTHESIA? Synesthesia is a condition in which one sense is simultaneously perceived by one or more additional sense. – For example, hearing being perceived as sight. Another form of synesthesia joins objects such as letters, shapes, numbers or people's names with a sensory perception such as smell, color or flavor.

4. WHAT IS SYNESTHESIA? Synesthesia can involve any of the senses. – The most common form, colored letters and numbers, occurs when someone always sees a certain color in response to a certain letter of the alphabet or number. For example, a synesthete (a person with synesthesia) might see the word "plane" as mint green or the number "4" as dark brown. – There are also synesthetes who hear sounds in response to smell, who smell in response to touch, or who feel something in response to sight. Just about any combination of the senses is possible. There are some people who possess synesthesia involving three or even more senses, but this is extremely rare.

5. DIAGNOSIS There is no officially established method of diagnosing synesthesia, some guidelines have been developed by Richard Cytowic, MD, a leading synesthesia researcher. – Not everyone agrees with Cytowic though.

6. Diagnosis Guidelines Involuntary: – synesthetes do not actively think about their perceptions; they just happen. Projected: – rather than experiencing something in the "mind's eye," as might happen when you are asked to imagine a color, a synesthete often actually sees a color projected outside of the body. Durable and generic: – the perception must be the same every time; for example, if you taste chocolate when you hear Beethoven's Violin Concerto, you must always taste chocolate when you hear it; also, the perception must be generic -- that is, you may see colors or lines or shapes in response to a certain smell, but you would not see something complex such as a room with people and furniture and pictures on the wall.

7. Diagnosis Guidelines Memorable: – often, the secondary synesthetic perception is remembered better than the primary perception; for example, a synesthete who always associates the color purple with the name "Laura" will often remember that a woman's name is purple rather than actually remembering "Laura." Emotional: – the perceptions may cause emotional reactions such as pleasurable feelings.

8. Who has it? Estimates for the number of people with synesthesia range from “1 in 200 to 1 in 100,000.” – There are probably many people who have the condition but do not realize what it is.

9. Synesthetes tend to be: Women: in the U.S., studies show that three times as many women as men have synesthesia; in the U.K., eight times as many women have been reported to have it. The reason for this difference is not known. Left-handed: synesthetes are more likely to be left-handed than the general population. Neurologically normal: synesthetes are of normal (or possibly above average) intelligence, and standard neurological exams are normal. In the same family: synesthesia appears to be inherited in some fashion; it seems to be a dominant trait and it may be on the X- chromosome.

10. The Biological Basis of Synesthesia Some scientists believe that synesthesia results from "crossed-wiring" in the brain. They hypothesize that “in synesthetes, neurons and synapses that are "supposed" to be contained within one sensory system cross to another sensory system”. – It is unclear why this might happen but some researchers believe that these crossed connections are present in everyone at birth, and only later are the connections refined. In some studies, infants respond to sensory stimuli in a way that researchers think may involve synesthetic perceptions. It is hypothesized by these researchers that many children have crossed connections and later lose them. Adult synesthetes may have simply retained these crossed connections

11. The Biological Basis of Synesthesia It is unclear which parts of the brain are involved in synesthesia. Richard Cytowic's research has led him to believe that the “limbic system is primarily responsible for synesthetic experiences”. – The limbic system includes several brain structures primarily responsible for regulating our emotional responses. – Other research, however, has shown “significant activity in the cerebral cortex during synesthetic experiences”. In fact, studies have shown a particularly interesting effect in the cortex: “colored-hearing synesthetes have been shown to display activity in several areas of the visual cortex when they hear certain words. In particular, areas of the visual cortex associated with processing color are activated when the synesthetes hear words”. Non-synesthetes “do not show activity in these areas, even when asked to imagine colors or to associate certain colors with certain words”.

12. Famous People with Synesthesia Vasily Kandinsky (painter, 1866-1944) Amy Beach (pianist and composer, 1867-1944) Olivier Messiaen (composer, 1908-1992) Charles Baudelaire (poet, 1821-1867) Franz Liszt (composer, 1811-1886) Arthur Rimbaud (poet, 1854-1891) Richard Phillips Feynman (physicist, 1918-1988) Mary J. Blige (singer, songwriter, 1971-)