1. Medical Microbiology MDL243 Dr. KHALID M ALJARALLAH MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 1

2. Medical Microbiology 1 st Lecture MDL243 MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 2

3. microorganisms that might live somewhere in or on your body. image via pharmaceutical microbiology.pharmaceutical microbiology http://battymsminton.blogspot.com/2012/06/original-human-social-network.html MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 3

4. Course organization Lab Reports 10 One assignment 10 Two mid-term Exams 2 x 15 = 30 Lab final exam 10 Final Exam 40 MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 4

5. This course will provide you with: Morphology of bacteria, structure of bacteria, difference between microbes, bacterial growth, relation between the host and microbial flora. Introduction in Immunology. Examples of pathogenic bacteria to humans (characteristics, transmission, diseases, prevention, diagnosis, treatment). Virology (general characteristics, structure, viral genetics, classification, diagnosis, examples of pathogenic diseases.) Mycology (importance of fungi, definitions, classification, structure, fungal multiplication, transmission, growth, diseases, treatment, examples of pathogenic fungi). Basics of parasitology, classification of parasites, transmission, examples of pathogenic parasites, treatment, lifecycles. MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 5

6. Main reference MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 6

7. References Microbiology. C. K. Paniker.1996. Medical Microbiology. David Green wood, Richard Slack, John Peutherer, Mike Barer. Churchill Livingstone 2007. Medical Microbiology. Jawetz, Melnick &Adelberg’s. Lange 2007. Foundations in Microbiology. Kathleen P. Talaro, 2004.USA. Medical Microbiology: A short Course. Baron, et al., 1994.Willey- Lis. Microbiology, Basic Principles and Clinical Application, Rose and Barron (1983) Biology of Microorganisms, Brock and Madigan (1988) Microbiology – Essential and Applications, International Edition. Larry McKane & Judy Kandel (1996) MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 7

8. History of Microbiology Some highlights – 1673 van Leeuwenhoek’s microscopes (animalcules not spontaneously) – 1857 Pasteur Fermentation (term Microorganism, development o vaccines against Anthrax, Chicken cholera and Rabies) – 1876 Koch - germ theory of disease (solid media, discovery of causative agents of; Tuberculosis, Cholera, Anthrax. Koch’s postulates. Lab animals) MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 8

9. Golden Age of Microbiology 1857 - 1914 Pasteur – Pasteurization – Fermentation Joseph Lister – Phenol to treat surgical wounds – 1 st attempt to control infections caused by microoganisms Robert Koch – Koch’s Postulates Edward Jenner – vaccination Paul Erlich – 1 st synthetic drug used to treat infections – Salvarsan - arsenic based chemical to treat Syphilis “salvation” from Syphilis MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 9

10. What is Microbiology? The study of the organisms that are invisible to the naked eye Includes: Bacteria Algae Fungi Protozoa Viruses MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 10

11. Microbes.. Harmful or Beneficial? 99% of microorganisms contribute to the quality of human life  Natural flora  Maintain balance of chemical elements in the natural environment (recycling carbon, nitrogen, sulfur..etc.)  Prevent infection by pathogens  Food & beverage production  ….. MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 11

12. Examples of beneficial Microorganisms MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 12

13. A minority cause disease! EX.  AIDS  Influenza  Salmonellosis  Botulism MDL243 - Dr. Khalid AlaraAlah - 2nd term 34/35 13