1. CHE5480 Summer 2005 Dendrimers June 14, 2005

2. Starburst Dendrimers

3. What is a dendrimer? Branched polymers ( dendron = tree in Greek) = 3 (Nitrogen) What is a dendrimer? Branched polymers ( dendron = tree in Greek) Functionality = 3 (Nitrogen)

4. Silicon, Si, functionalty f=4

6. Rose bengal inside PPI dendrimer.

7. Dendrimers: 1. Manufacture 2. Structure 3. Characterization 4. Applications

8. Manufacture: (i) Divergent Method (ii) Convergent Method

9. Methods of Synthesis: (i) Divergent Growth

10. Methods of Synthesis: (ii) Convergent Growth

11. Comparison: Divergent vs. Convergent

12. Structure:

14. Generations of Dendrimers 2 nd gen. 4 th gen. 5 th gen.

16. PAMAM Dendrimer (polyamidoamine) Alternating (B)-AB-AB-AB-... Ethylenediamine (B) H 2 N-C-C-NH 2 Methylacrylate (A) C=C-CO-OCH 3

17. PAMAM Moieties: Acrylate Diamine NH 3 or Diamine

19. Characterization:

20. f=3fc=3 Spacer b 1 2 3 generations

21. Construction of Generations: Core: Ethylenediamine (Moiety B = D) “Michael Addition” of 4 Methylacrylates (A= O) Amidization: add 4 ethyldiamines (D) Result: Generation “0”

22. Continue Branching: Generation “1”:

23. Generation “2”:

24. Calculations: Note that Core functionality (2 nitrogens): fc = 4 Branch functionality (nitrogen): f=3 No. of Spacers (A+B): b=2 Generation = G

25. Number of Branches: N br

26. Number of Mers (A+B): N mer

27. Applications of Dendrimers Gas and chemical sensors Catalysts Drug delivery and gene therapy Surface modifiers (tribology, and information storage) Bio compatible materials Electronic devices and antennae

30. Size of PAMAM Dendrimers Generation M.W. Angstrom (dia.) End Gps (1 nm = 10 Angstroms)

31. Equivalent Sizes with Cells:

32. Dendrimer: PAMAM

33. 2. Nanostructured materials: Gas adsorption in dendrimers