1. What is this? What can it be used for?

2. Objectives Explore the inheritance of genetic disease in particular with reference to cystic fibrosis and Huntington’s disease. Outcomes 3: Outline the causes and symptoms of some genetic diseases. 5: Explain the inheritance of genetic diseases. 7: Evaluate the social and economic impact on people diagnosed with genetic diseases, including the benefits and drawbacks of screening. Key terms: Genetic, inherited, disease, screening.

3. Many genetic diseases in humans are a result of recessive alleles of autosomal (sex) genes. Although some are due to dominant or dominant alleles. Autosomal recessive: Tay -sachs, cystic fibrosis, Medium-chain acyl-CoA dehydrogenase deficiency (MCADD). Dominant: Marfan syndrome, Autosomal dominant polycystic kidney disease, huntington’s. Co-dominant: sickle cell anaemia (mild unless two recessive alleles, but will infer malaria resistance) Outcomes 3: Outline the causes and symptoms of some genetic diseases. 5: Explain the inheritance of genetic diseases. 7: Evaluate the social and economic impact on people diagnosed with genetic diseases, including the benefits and drawbacks of screening. Key terms: Genetic, inherited, disease, screening.

4. Task In groups you are going to put together a presentation a genetic disease (cystic fibrosis or Huntington’s) and deliver it at the end of the lesson This should cover: Symptoms How the disease is inherited A pedigree chart to show the inheritance Outcomes 3: Outline the causes and symptoms of some genetic diseases. 5: Explain the inheritance of genetic diseases. 7: Evaluate the social and economic impact on people diagnosed with genetic diseases, including the benefits and drawbacks of screening. Key terms: Genetic, inherited, disease, screening.