1. SARC Restructuring

2. SARC Strategic Plan  Mission  Given there is no successful structure in the US to provide platform to make progress in the diagnosis and treatment of sarcoma, SARC exists to fill that void  Vision/Future picture of success  Bring to the public new and effective therapies that will reduce pain and suffering for sarcoma patients  Provide stimulus for the recruitment and training of the brightest and best clinician scientists to choose to study sarcoma in the future  Through collaboration and pooling of intellect, identify new and effective therapies  Establish SARC as the academic “voice” of sarcoma expertise  Provide stimulus and infrastructure for exchange of ideas

3. SARC Organization Chart Board of Directors: Chairman of the Board Finance Committee: Treasurer Executive Committee: President/Chief Operating Officer CommitteesMedical OfficerOperations Office Career Development Developmental Therapeutics Participants SPORE

4. Participation Committee  Suzanne George, MD  Chair  Committee Members  Paul Meyer, MD  Margaret von Mehren, MD

5. SARC Participation  Criteria  Membership in CTOS  Site Principal Investigator  80 or more new cases per year  Annual review/renewal

6. SARC Medical Officer  Medical Officer role  Coordinate review of new concepts, protocols, and manuscripts  Chair monthly review of all ongoing studies  Respond to specific medical inquiries  Oversight of safety  Resource to project managers at SARC  Work with study PIs

7. Clinical Trial Concept  New study proposal  Submit to Medical Officer  SARC to post format at website  Process for review  Medical officer to present to Executive Committee for consideration in relation to strategic direction  Approved concepts/protocol development  SARC protocol template  Medical officer and SARC operations staff support