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Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,

Published byKerry King Modified over 8 years ago

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Presentation on theme: "Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,"— Presentation transcript:

1 Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser, Hui Hao-Shen, Ina Nissen, Sabine Girsberger, Thomas Lehmann, Jakob Passweg, Martin Stern, Christian Beisel, Robert Kralovics, and Radek C. Skoda Blood Volume 123(14):2220-2228 April 3, 2014 ©2014 by American Society of Hematology

2 Targeted NGS in MPN: study design and workflow. Pontus Lundberg et al. Blood 2014;123:2220-2228 ©2014 by American Society of Hematology

3 Frequency and distribution of mutations in patients with MPN. (A) Number of patients with mutations in the genes is indicated. Pontus Lundberg et al. Blood 2014;123:2220-2228 ©2014 by American Society of Hematology

4 Analysis of sequential samples: clinical correlations and risk stratification. Pontus Lundberg et al. Blood 2014;123:2220-2228 ©2014 by American Society of Hematology

5 Clonal evolution in MPN patients carrying somatic mutations in epigenetic modifier genes. Pontus Lundberg et al. Blood 2014;123:2220-2228 ©2014 by American Society of Hematology

6 Model of MPN disease evolution and risk stratification in correlation to mutational events. Pontus Lundberg et al. Blood 2014;123:2220-2228 ©2014 by American Society of Hematology

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