1. Photodynamic Therapy

2. Phototherapy
The first who used the light: Egyptians, Indians, Chinese and Grecee
1815. Carvin
1822. Sniadecki
1903. D. N. Finsen: Nobel Prize

3. Photochemotherapy
Indians: Psoralea corylifolia
Egyptians: Ammi majus

4. PDT history
1900. Oscar Raab
1905. H. von Tappeiner take in the PDT

5. Hematoporphyrin
1841. Sherer
1867. Thudicum
1871. Hoppe- Seyler

6. Hematoporphyrin 1924. Policard Auler and Banzer
Figge and co workers: photodiagnosis

9. Why do some photosensitiziers localize selectively in tumors?
Tumors have a larger interstital volume than normal tissues
Tumors often contain a larger fraction of macrophages than normal tissues
Tumors have a leaky microvasculature
Tumors have poor lymphatic drainage
The extracellular ph is low in tumors
Tumors contain a relatively large amount of newly synthesized collagen
Tumor tissue contains many receptors for lipoproteins

10. Use photosensitizing solution
PDT treatment
Use photosensitizing solution
Collect in cancer
Irradiate
Selective tumour collapse

11. Porfirin

12. PDT mechanism
Energy transport  reactive oxygen

13. PDT mechanism
Electron passing  free radical

14. PDT mechanism photosensitizing Activation with light
Introduce photosensitizing into the cell
release reactive oxygen
end free radical
tissue
necrosis or apoptozis

15. Other tumour therapy Surgery Radio- and chemotherapy
disadvantage: - can’t remove total the cancer
- matastasis
Radio- and chemotherapy
disadvantage: - to hight degree damage
- resistance

16. Photodynamic Therapy Advantage - selective destruction
- not develop resistance
Disadvantage
- only use surface cancer
- cell of small size

17. Other field of application
Arteriosclerosis
Germ, virus inanctivation
Gum inflammation
Blood sterilization
Water purification

18. Thank you for your patience