1. Figure 8.1 The Biology of Cancer (© Garland Science 2007)

2. Figure 8.3b The Biology of Cancer (© Garland Science 2007)

3. Kinetics of Cyclin D1 after mitogenic stimulus
Figure 8.8 The Biology of Cancer (© Garland Science 2007)

4. Many Growth Factor-Stimulated Pathways Upregulate Cyclin D

5. Waxing & Waning of Cyclin-CDK Complexes
Figure The Biology of Cancer (© Garland Science 2007)

6. Families of Cyclin-CDK Inhibitors

7. Figure 8.14a The Biology of Cancer (© Garland Science 2007)

8. Figure 8.15a The Biology of Cancer (© Garland Science 2007)

9. Recall the AKT/PKB – mTOR Axis
Figure 16.44a The Biology of Cancer (© Garland Science 2007)

10. AKT Directs Growth-Sparing Compartmentation of p27Kip1 (and p21Cip1 too)
Figure 8.16b The Biology of Cancer (© Garland Science 2007)

11. Paradoxical Effects of p21 and p27 on Cyclin D-CDK4/6 VS other Cyclin-CDKs
Figure 8.17a The Biology of Cancer (© Garland Science 2007)

12. Rb’s Actions are Regulated by its State of Phosphorylation

13. Phosphorylation Determines Rb-E2F Interaction
Figure The Biology of Cancer (© Garland Science 2007)

14. + Feedback loop Cyc E-CDK2 Promotes Destruction of p27
Cyclin E transcription
Figure 8.25b The Biology of Cancer (© Garland Science 2007)

15. The Rb Family of Pocket Proteins p105 (Rb); p107 & p130
Figure 8.21a The Biology of Cancer (© Garland Science 2007)

16. E2F/DP and Transcription
(Associated with Hypophosphosphorylated Rb family members)
(Free E2F-DP complexes)

17. During G1Cooperation Among Pathways (mostly) Favors D1 Accumulation
Figure The Biology of Cancer (© Garland Science 2007)

18. Myc, Max & Mad-Max
Figure The Biology of Cancer (© Garland Science 2007)

19. Myc & Its Collaborators Promote D/CDK & Decrease Rb Inhibition of R Point Transit
Figure The Biology of Cancer (© Garland Science 2007)

20. TGFβ can Trump Myc
Figure The Biology of Cancer (© Garland Science 2007)

21. Myc can Influence Differentiation
Figure The Biology of Cancer (© Garland Science 2007)

22. A Web of Interactions & Pathways Influence R Point Transition
Figure The Biology of Cancer (© Garland Science 2007)