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This article and any supplementary material should be cited as follows: Loerakker S, Huisman ES, Seelen HA, Glatz JF, Baaijens FP, Oomens CW, Bader DL.

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Presentation on theme: "This article and any supplementary material should be cited as follows: Loerakker S, Huisman ES, Seelen HA, Glatz JF, Baaijens FP, Oomens CW, Bader DL."— Presentation transcript:

1 This article and any supplementary material should be cited as follows: Loerakker S, Huisman ES, Seelen HA, Glatz JF, Baaijens FP, Oomens CW, Bader DL. Plasma variations of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects. J Rehabil Res Dev. 2012;49(3):361–72. http://dx.doi.org/10.1682/JRRD.2011.06.0100 Slideshow Project DOI:10.1682/JRRD.2011.06.0100JSP Plasma variation of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects Sandra Loerakker, MSc; Elise S. Huisman, MSc; Henk A. M. Seelen, PhD; Jan F. C. Glatz, PhD; Frank P. T. Baaijens, PhD; Cees W. J. Oomens, PhD; Dan L. Bader, PhD

2 This article and any supplementary material should be cited as follows: Loerakker S, Huisman ES, Seelen HA, Glatz JF, Baaijens FP, Oomens CW, Bader DL. Plasma variations of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects. J Rehabil Res Dev. 2012;49(3):361–72. http://dx.doi.org/10.1682/JRRD.2011.06.0100 Slideshow Project DOI:10.1682/JRRD.2011.06.0100JSP Aim – Investigate circulatory levels of biomarkers for muscle damage. Explore possibility of using them to detect deep pressure ulcers. Relevance – Deep pressure ulcers are major problem for people with spinal cord injury (SCI) Initial damage often hidden underneath intact skin. – Early detection is difficult and treatment is problematic.

3 This article and any supplementary material should be cited as follows: Loerakker S, Huisman ES, Seelen HA, Glatz JF, Baaijens FP, Oomens CW, Bader DL. Plasma variations of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects. J Rehabil Res Dev. 2012;49(3):361–72. http://dx.doi.org/10.1682/JRRD.2011.06.0100 Slideshow Project DOI:10.1682/JRRD.2011.06.0100JSP Methods In small groups of nondisabled subjects and subjects with SCI, we measured 5-day baseline concentrations of: – Creatine kinase. – Myoglobin (Mb). – Heart-type fatty acid binding protein (H-FABP). – C-reactive protein (CRP).

4 This article and any supplementary material should be cited as follows: Loerakker S, Huisman ES, Seelen HA, Glatz JF, Baaijens FP, Oomens CW, Bader DL. Plasma variations of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects. J Rehabil Res Dev. 2012;49(3):361–72. http://dx.doi.org/10.1682/JRRD.2011.06.0100 Slideshow Project DOI:10.1682/JRRD.2011.06.0100JSP Results Each subject had unique marker concentration profile. Mb and H-FABP were correlated for both subject groups. – No significant differences in marker concentrations between groups, although trend toward higher CRP was observed in SCI subjects. One SCI subject with category II pressure ulcer had higher H-FABP and CRP concentrations than all other subjects.

5 This article and any supplementary material should be cited as follows: Loerakker S, Huisman ES, Seelen HA, Glatz JF, Baaijens FP, Oomens CW, Bader DL. Plasma variations of biomarkers for muscle damage in male nondisabled and spinal cord injured subjects. J Rehabil Res Dev. 2012;49(3):361–72. http://dx.doi.org/10.1682/JRRD.2011.06.0100 Slideshow Project DOI:10.1682/JRRD.2011.06.0100JSP Conclusions Variations in each marker concentration were smaller than predicted increases after pressure ulcers. – Therefore, this combination of plasma markers may prove appropriate for early detection of deep pressure ulcers.

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