Presentation is loading. Please wait.

Presentation is loading. Please wait.

Modelling from Sequence to Gene Regulatory Network to Phenotype.

Similar presentations


Presentation on theme: "Modelling from Sequence to Gene Regulatory Network to Phenotype."— Presentation transcript:

1 Modelling from Sequence to Gene Regulatory Network to Phenotype

2 Network Expression The gene regulation network expresses as gene activation over time 1 5 3 4 2 Time 1 2 3 4 5 Gene activation

3 State Spaces If the system state at a given time step is determined by the previous system state, the dynamics can settle into ‘basins of attraction’, in which the system is robust to perturbation. But some changes can push the system to different behaviour. 1 5 3 4 2

4 System State After Single Perturbations

5 Perturbation

6 System State After Single Perturbations

7 Perturbation

8 System State After Single Perturbations

9 Perturbation

10 System State After Single Perturbations

11 Perturbation

12 System State After Single Perturbations The dynamics of the system have changed

13 System State After Single Perturbations Perturbation

14 System State After Single Perturbations The system has changed again

15 Such complex systems dynamics are being studied in models of gene regulation

16 System State After Single Perturbations


Download ppt "Modelling from Sequence to Gene Regulatory Network to Phenotype."

Similar presentations


Ads by Google