1. Natural Selection Variation

2. Natural Selection Variation Heredity

3. Natural Selection Variation Heredity Differential Survival

4. 4 Fitness Landscape Sewell Wright (1899-1988)

5. Multi-dimensional spaces {x,y,z} {x,y,z,a,b,c,d,e}Generalize to:

6. Multi-dimensional spaces {x,y,z} {x,y,z,a,b,c,d,e}Generalize to: Show K-means model

7. 7 Fisher’s Fundamental Theorem R. A. FisherR. A. Fisher's so-called fundamental theorem of natural selection:atural "The rate of incr"The rate of increase in fitness of any organism at any time is equal to its genetic variance in fitness at that time." [1]is equa Or, in more modern terminology: "The rate of increase in the mean fitness of any organism at any time ascribable to natural selection acting through changes in gene frequencies is exactly equal to its genetic variance in fitness at that time". [2]te ic variance in f Ronald Fisher (1890-1962)

8. Information and Matter Natural history Evolvability Modularity: Evo Devo Evolution of Cooperation/Eusociality

9. DNA

11. Transcription

12. Translation Notion of “gene expression”

13. Epigenetics From Wikipedia: “Epigenetics is the study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence.” http://www.pbs.org/wgbh/nova/body/epigenetics.htmhttp://www.pbs.org/wgbh/nova/body/epigenetics.html Is epigenetics why cloned animals don’t fare well?

14. Genetic regulation

15. Genetic Switches (in “non-expressed” regions) Lac Operon http://www.youtube.com/watch?v=oBwtxdI1zvk

16. Genetic Regulatory Networks

17. Random Boolean Networks as models of genetic regulatory networks