1. leptospirosis

2. Definition
Leptospirosis is a bacterial disease related to genus Leptospira which cause septicemia, It is rare in cats but more common in dogs, cattle
Leptospirosis is a zoonotic disease (human).
NB:
In man: it causes Weil’s disease

3. Uterus in pregnant animal
pathogenesis
penetration
fever
Localized in
lung
liver
jaundice
kidney
brain
Uterus in pregnant animal
abortion

4. Septicemia on serous membranes (pleura )
septicemia leads to petechial hemorrhages and edema
on serous membranes (pleura )
:may be seen in other organs as myocardium ,
adrenal glands,
pancreas,
gallbladder
and lung

5. Pulmonary hemorrhage

6. A-Canine Leptospirosis:
Pathognomonic Lesions:
Acute leptospirosis:
Liver:
Macroscopic Picture :
1-The liver is enlarged and yellow in color.
2-Yellow m.m. due to icterus.
3-Peticheal hemorrhages on the pleura, pericardium and peritoneum.

7. Icterus

8. Microscopic Picture: 1- coagulative necrosis in hepatic cells.
2-Dissociation of the hepatic cells (individualization).
3-hemolytic jaundice with dilation of the bile canaliculi with yellow bile pigments.
4-Hemosiderosis are seen in the kupffer cells. .

10. Organ : Liver.
Stain : H&E.
Micro : Dissociation and individualization hepatic cells.

11. B- Bovine leptospirosis
Subacute and Chronic leptospirosis:
Macroscopic Picture:
1-The kidneys are enlarged & atrophied (chronic).
2-Grayish-white spots throughout the cortex (white spotted kidney) and
the capsule is not easily detached.
3-Smooth or pitted surface with hemorrhage at the corticomedullary
junction. .

14. Microscopic Picture: 1-Agggregations of lymphocytes
2-Extenssive coagulative necrosis.
3-Fibrosis and cystic dilation of some renal tubules in chronic stage.
4-Cellular and hyaline casts

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