1. A Strategy for Assessing and Managing Occupational Exposures Exposure Assessment Basic Characterization Start Unacceptable AcceptableUncertain Control Measures Further Information Gathering Periodic Re-Assessment

2. How do we develop the comprehensive metrology, instrumentation, and standards to support a nanotechnology ESH program?

3. Exposure Management Control banding - concept Low DustinessMedium DustinessHigh Dustiness Hazard Group A Small111 Medium112 Large122 Hazard Group B Small111 Medium122 Large133 Hazard Group C Small112 Medium233 Large244 Hazard Group D Small223 Medium344 Large344 Hazard Group E For all hazard group E substances, choose control approach 4 Parameters Amount Used Dustiness Hazard Group (R-Phrase) Control Approach 1.General Ventilation 2.Engineering Control 3.Containment 4.Specialist Advice www.ilo.org NIOSH: TJ Lentz

4. A requirement from the U.K. Regulations on Control of Substances Hazardous to Health (COSHH) COSHH requires you to carry out health surveillance in the following circumstances: where employees are exposed to a substance linked to a particular disease or adverse health effect and there is a reasonable likelihood, under the conditions of the work, of that disease or effect occurring and it is possible to detect the disease or health effect. Reference: COSHH: A brief guide to the Regulations What you need to know about the Control of Substances Hazardous to Health Regulations 2002 (COSHH), Health and safety Executive, INDG136rev3 04/05 C2000 (April 2005).

5. Comprehensive Industrial Hygiene Program Functional Elements Exposure Monitoring Engineering Controls Hazardous Materials Management Hazard Communication Hearing Conservation Personal Protective Equipment Medical Surveillance Epidemiology Studies Exposure Assessment

6. Particle Categories Classes of engineered nanoparticles A.Spherical homogeneous B.Fibrous homogeneous C.Non-spherical homogeneous D.Agglomerate homogeneous E.Heterogeneous concentric F.Heterogeneous distributed G.Heterogeneous agglomerate H.Active particle I.Multifunctional particle (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars

7. Particle Categories Classes of engineered nanoparticles A.Spherical homogeneous (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars

8. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars B.Fibrous homogeneous

9. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars C.Non-spherical homogeneous

10. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars D.Agglomerate homogeneous

11. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars E.Heterogeneous concentric

12. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars F.Heterogeneous distributed

13. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars G.Heterogeneous agglomerate

14. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars H.Active particle

15. Particle Categories Classes of engineered nanoparticles (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars I.Multifunctional particle

16. Particle Categories Classes of engineered nanoparticles A.Spherical homogeneous B.Fibrous homogeneous C.Non-spherical homogeneous D.Agglomerate homogeneous E.Heterogeneous concentric F.Heterogeneous distributed G.Heterogeneous agglomerate H.Active particle I.Multifunctional particle (not necessarily inclusive) Dr. Andrew D. Maynard: Woodrow Wilson International Center for Scholars

18. –Approaches to Safe Nanotechnology is a dynamic document about which NIOSH seeks public input, and that NIOSH will periodically update. –Developing a comprehensive, centralized information management system across agencies and organizations would be a significant contribution www.cdc.gov/niosh/topics/nanotech

19. The findings and conclusions of this presentation have not been formally disseminated by the National Institute for Occupational Safety and Heath and should not be construed to represent any agency determination or policy. Mention of company or product does not constitute endorsement by the Centers for Disease Control and Prevention or the National Institute for Occupational Safety and Health. The assistance of many colleagues in the NIOSH Nanotechnology Research Program and our partnering organizations is gratefully acknowledged. Mark.Hoover@cdc.hhs.govMark.Hoover@cdc.hhs.gov 304-285-6374 Vladimir.Murashov@cdc.hhs.govVladimir.Murashov@cdc.hhs.gov 202-401-3737