1. Lacie Smith April 22, 2005 Department of Chemistry and Biochemistry Can we fix it! Yes we can! Synthesis of Novel Quorum Sensing molecules

2. Bacteria What are bacteria? How do bacteria communicate with one another? Quorum sensing

3. Research Questions By making new signaling molecules which resemble the bacterial signaling molecule: Will we be able to interfere with the bacterial communication? Will a damaging agent attach to the signaling molecules so that the bacteria cells will be killed?

4. Goal To make several similar compounds with a variation in “R” group

5. Methods Overall Scheme:

6. Why is this project important?  Would benefit the medical, sewage, and marine environment  Would offer a new approach in fighting infections

7. References Bassler Bonnie: How bacteria talk to each other: regulation of gene expression by quorum sensing, Microbiology 1999, 2:582-587. Brelles-Marino G; Bedmar E.; Journal of Biotechnology 91 2001, 197-209 March J, Bentley W: Quorum sensing and bacterial cross-talk in biotechnology. Biotechnology 2004,15:495-502.