1. If F {f(x,y)} = F(u,v) or F( ,  ) then F( ,  ) = F { g  (R) } The Fourier Transform of a projection at angle  is a line in the Fourier transform of the image at the same angle. The Central Section Theorem is also referred to as the projection- slice theorem. Central Section or Projection Slice Theorem

2. π ∞ ∫ d  ∫ F -1 { F {g  (R) } |p| }  ( x cos  + y sin  - R) dR 0 -∞ CT Reconstruction Methods - Filtered Back Projection Each projection is filtered to account for oversampling of lower spatial frequencies before back projection. Here filtering is done in the frequency domain

3. π ∞ ∫ d  ∫ [ g  (R) * c (R) ]  ( x cos  + y sin  - R) dR 0 -∞ Same idea as filtered back projection, but filtering is done in projection domain. Here each projection is convolved with c (R) and then back projected. Describe c (R) C (p) = |p| c (R) = lim 2 (  2 - 4π 2 R 2 ) / (  2 + 4π 2 R 2 ) 2   0

4. I0I0  (x,y) I = I 0 e - ∫  dl ln (I 0 / I) = ∫  dl Assumptions - zero width pencil beam - monoenergetic Look at horizontal and vertical projection measure of attenuation at point P. How will bone affect the vertical projection? Bone CT Artifacts: Beam Hardening P

5. Should get same answer for each projection. Bone attenuates Cupping artifact Soft tissue cannot demonstrate its attenuation  no photons to show it Normal emitted energy spectrum How does beam look after moving through bone tissue? E Relative Intensity

6. First Generation CT Scanner From Webb, Physics of Medical Imaging

7. Physics of Medical Physics, EditorWebb

8. Interpolation during Back Projection

9. Second Generation CT Scanner From Webb, Physics of Medical Imaging

10. 3 rd and 4 th Generation Scanners From Webb, Physics of Medical Imaging

11. Electron Beam CT

12. Krestel- Imaging Systems for Medical Diagnosis

13. Krestel- Imaging Systems for Medical Diagnosis

14. Krestel- Imaging Systems for Medical Diagnosis

15. Sampling Requirements in CT How many angles must we acquire? Samples acquired by each projection are shown below as they fill the F(u,v) space. F(u,v) u v

16. Impulse Response Impulse response h(x,y) F(u,v) u v Let’s assume that the CT scanner acquires exact projections. Then the impulse response is the inverse 2D FT of the sampled pattern. Inverse 2D FT

17. Impulse response Bright white line points to correctly imaged impulse. Inside of White circle shows region that is correctly imaged Region outside of white circle suffers streak artifacts. How big is the white circle? –How does it relate to the number of angles? –Easier to think of in frequency domain Impulse response h(x,y)

18. Recall: Band limiting and Aliasing F{ g(x)} = G(u) G(u) is band limited to u c, (cutoff frequency) Thus G(u) = 0 for |u| > u c. ucuc To avoid overlap (aliasing) with a sampling interval X, ucuc Nyquist Condition: Sampling rate must be greater than twice the frequency component.

19. Apply to Imaging F {g(x,y)}= G(u,v) g(x,y) G(u,v) If we sample g(x,y) at intervals of X in x and y, then G(u,v) replicates u v 1/X G(u,v) ^

20. Sampling in Frequency Domain If we sample in the frequency domain, then the image will replicate at 1/frequency sampling interval. Intersections depict sampling points. Let sampling interval in frequency domain be equal in each direction and be  F. Then we expect the images to replicate every 1/  F G(u,v) FF

21. 1/  F = FOV FOV

22. How many angles do we need?  … FF Three angles acquired from a CT exam are shown, each acquired  apart. Data acquisition is shown in the Fourier space using the Central Section Theorem. The radial spacing,  F , is the separation between the vertical hash marks on the horizontal projection. If we consider what the horizontal projection will look like as it is back projected, we can appreciate that 1/  F  = Field of View.

23. How many angles do we need?  … FF To avoid aliasing of any spatial frequencies, the spacing of the points in all directions must be no larger than  F  The largest spacing between points will come along the circumference. If we scale the radius of the circle so it has radius 1, the circumference will be 2  However, we only need projections to sample a distance of  since one projection will provide two points on the circle.

24. How many angles do we need?  … FF To avoid aliasing of any spatial frequencies, the spacing of the points in all directions must be no larger than  F  The largest spacing between points will come along the circumference. If we scale the radius of the circle so it has radius 1, the circumference will be 2  However, we only need projections to sample a distance of  since one projection will provide two points on the circle.

25. How many angles do we need?  … For  a radius of 1 or diameter of 2,  F  2/N where N is the number of detectors. That is, there are N hash marks ( samples) on the projection above. The spacing of points on the circumference will then be  /M where M is the number of projections. So the azimuthal spacing on the circumference,  /M,must be equal or smaller to the radial spacing 2/N. Solving for M gives M=  /2 * N

26. Azimuthal Sampling requires M angles = π/2 N detector elements Azimuthal Undersampling a)Sampling Pattern - frequency space or projections acquired b)Plot of one line of 2D impulse response c)2D impulse response with undersampling d)Image of a Square What causes artifacts? Where do artifacts appear?