1. Functional Anatomy of Lymphatic System

2. Lymphatic System Core Functions  protects body against foreign material  assists in circulation of body fluids between cells and bloodstream  transports dietary fats

3. Components of the Lymphatic System  Consists of: - lymph - network of vessels - lymph nodes and nodules - tonsils - spleen - thymus gland - bone marrow

4. Note how Lymphatic Tissue is laced within capillary beds, allowing for transport of cellular fluid into Lymphatic system.

5. Lymph (lympha = clear fluid)  derived from tissue fluid  contains more white blood cells than plasma  enters node through afferent (in-coming) lymphatic vessels  flows through node in one direction

6. Lymph (lympha = clear fluid)  flows through sinuses in lymph node cortex and then into the medulla  exits the lymph node through efferent lymphatic vessels  must be returned to blood stream to maintain blood volume and pressure

7. The Lymphatic System - network of vessels - lymph nodes and nodules - tonsils - spleen - thymus gland - bone marrow

8. Lymph Capillaries  microscopic closed-ended vessels  located next to blood capillaries in tissue spaces  larger diameter than blood capillaries  are very permeable and collect tissue fluid and proteins  lymph capillaries merge to form larger lymph vessels

9. Lymph Vessels  Lymph vessels resemble veins but have thinner walls and more valves  ends of endothelial cells overlap - act as one-way valves allowing interstitial fluid to flow in but not out  attached to surrounding tissue by anchoring filaments

10. Lymph Vessels  no pump for lymph  Lymph is kept moving by: - constriction of vessels - skeletal muscle pump - respiratory pump  at intervals along vessels lymph flows into lymph nodes  lymphatic vessels unite to form lymph trunks

11. Lymph Vessels  Lymph empties into two conducting ducts: - the thoracic duct (left lymphatic duct) - the right lymphatic duct Lymph from these ducts enters the blood stream via the left subclavian vein and the right subclavian vein

12. Lymph Nodes  The Lympthatic System

13. covered by a capsule contain capsular extensions called trabeculae (form partitions within node) internal to capsule are reticular fibers and fibroblasts - form framework of a lymph node Two main regions of a lymph node: - cortex - medulla Lymph Nodes

14. largest lymphatic organ located in upper left abdominal quadrant 5-6 inches long, 2-3 inches wide resembles a large lymph node filters blood - cortex - medulla Spleen … a giant Lymph Node?

15. Spleen White Pulp  consists of lymphatic tissue, mostly lymphocytes (white blood cells) arranged around central arteries Red Pulp  venous sinuses filled with blood - cords of splenic tissue, consists of red blood cells, macrophages (big eaters), lymphocytes (T and B cells, NK cells), plasma cells (secrete antibodies), and granulocytes

17. Spleen Functions of the Spleen phagocytosis of bacteria and worn out or damaged red blood cells and platelets stores and releases blood in times of demand, e.g., hemorrhage functions in immunity as a site of B cell proliferation into plasma cells does not filter lymph because it has no afferent lymphatic vessels or lymph sinuses

18. Spleen Removal of Spleen (splenectomy)  can be removed b/c other organs, e.g. the liver and bone marrow can compensate for it  increased susceptibility to disease may result

19. Thymus Gland  two-lobed organ located in upper part of chest along trachea  inferior to thyroid gland, posterior to sternum  largest and most active during prenatal period and infancy  after puberty it decreases in size

20. Thymus Gland  composed of lymphatic tissue; subdivided into lobules  immature T cells originating in the bone marrow migrate to thymus via blood (cell-mediated immune response)  in thymus, cells develop into mature T cells for release into circulation (travel to lymph nodes, spleen, and diffuse lymphatic tissues)  thymic (from thyroid) hormones aid in maturation of T cells

21. Removal of Thymus (thymectomy)  can be removed but decreased T-cell production results  possible acute susceptibility to infection Thymus gland as sized at birth shown by rubber model on baby's chest.