1. Androgenic Steroids Overall Organization of the Topic
Overall mechanism of steroid hormone action
Structure of male sex hormones
- Testosterone, androstendione, and 5a-dihydrotestosterone
Nomenclature of androgenic steroids
Physiological activities
- Androgenic and anabolic activities
Biosynthesis and metabolism of testosterone
Structure activity relationships
- Generalizations
Androgen antagonists
- Finasteride, danazol, bicalutamide and flutamide

2. Steroid Hormones Overall Mechanism of Steroid Hormone Action
(intracellular)
(intranuclear)
proteins
Intracellular effects
extracellular effects
transcription
translation
dimerization
DNA
(extracellular)

3. Androgenic Steroids Structure and Nomenclature Testosterone
Androstendione
(Andro)
(17b-hydroxy-androst-4-en-3-one)
3D-structure
(androst-4-en-3,17-dione)
5a-Dihydro-testosterone
(17b-hydroxy-5b-androstan-3-one)
3D-structure

4. Androgenic Steroids – Physiological Activities
Primarily two activities – Androgenic and Anabolic
Androgenic Activity
Growth and development of male sex organs
Important for male sex drive and performance
Development of secondary sexual characteristics
Important role in spermatogenesis
Anabolic Activity
Development of muscle mass
Reverse catabolic or tissue-depleting processes

5. Androgenic Steroids - Physiological Activities
Andro is available over the counter!!

6. Biosynthesis and Metabolism of Testosterone
Cholesterol
Pregnenolone
Testosterone
Other metabolites
5a-DHT
Androstendione

7. Structure Activity Relationships in Androgens
Anabolic Androgenic
Testosterone
(injectable)
Testosterone
esters (injectable)
R = COCH2CH propionate
= CO(CH2)5CH enanthate
= COCH2CH2(C5H9) cypionate

8. Structure Activity Relationships in Androgens
Anabolic Androgenic
17a-methyl
Testosterone
(oral)
Fluoxymesterone
(oral)

9. Structure Activity Relationships in Androgens
Anabolic Androgenic
Nandrolone
(injectable)
Oxymetholone
(oral)

10. Structure Activity Relationships in Androgens
Anabolic Androgenic
Stanozolol
(oral)
Dromostanolone
(oral)

11. Structure Activity Relationships in Androgens
17a-methyl testosterone
(10-50 mg/day)
Ethylestrenol (4 mg/day)
Oxandrolone (5-10 mg/day)
Methenolone acetate (20 mg /wk)
Norethandrolone
10-30 mg/day
Chlorotestosterone acetate (20 mg / wk)

12. Androgens Antagonists
Danazol
(endometriosis)
Finesteride
(baldness)
Bicalutamide
(prostate cancer)
Flutamide
(prostate cancer)