1. Role(s) of Interleukin 2By
Shoba Satkuru
MSc Biomedical Immunology

2. Properties of Interleukin 2
Source- Mainly by activated T-cells expressing CD surface Ag
Structure- 133 amino acids kDa in weight

3. Genetic Structure Receptors Contains 4 exons
Synthesis regulated at level of transcription
Receptors
Mediated by membrane receptors
3 types: High Affinity Intermediate Affinity Gamma Subunits

4. Biological Activities and Functions
Stimulates T cell proliferation
Stimulates B cell growth/differentiation
Generates Lymphokine activated killer cells (LAK cells)
Activates macrophages
Stimulates T cells to produce other cytokines
Stimulates proliferation of oligodendrocytes

5. Clinical Use & Significance
Transgenic animals, knock-out and antisense studies
Anti-tumor activity
Adoptive Immunotherapy
Treatment of cellular immunodeficiency diseases