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Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study by David M.

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Presentation on theme: "Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study by David M."— Presentation transcript:

1 Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study by David M. Ross, Susan Branford, John F. Seymour, Anthony P. Schwarer, Christopher Arthur, David T. Yeung, Phuong Dang, Jarrad M. Goyne, Cassandra Slader, Robin J. Filshie, Anthony K. Mills, Junia V. Melo, Deborah L. White, Andrew P. Grigg, and Timothy P. Hughes Blood Volume 122(4):515-522 July 25, 2013 ©2013 by American Society of Hematology

2 Rate of TFR in all 40 patients. David M. Ross et al. Blood 2013;122:515-522 ©2013 by American Society of Hematology

3 Response to retreatment with IM after molecular relapse. David M. Ross et al. Blood 2013;122:515-522 ©2013 by American Society of Hematology

4 BM qRT-PCR is not clinically useful as a predictor of molecular relapse. David M. Ross et al. Blood 2013;122:515-522 ©2013 by American Society of Hematology

5 BCR-ABL DNA evidence of residual disease in patients with UMRD. (A) Results of BCR-ABL DNA monitoring for 13 patients in TFR. Solid triangles indicate that BCR-ABL DNA was detected; open triangles indicate that BCR-ABL DNA was not detected. David M. Ross et al. Blood 2013;122:515-522 ©2013 by American Society of Hematology


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