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 Maintain internal homeostasis.  Regulate body temperature  Maintain tissue and cellular pH.

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Presentation on theme: " Maintain internal homeostasis.  Regulate body temperature  Maintain tissue and cellular pH."— Presentation transcript:

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2  Maintain internal homeostasis.  Regulate body temperature  Maintain tissue and cellular pH.

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13  Cardiac fibroblast  Vascular cells  Purkinje cells  Connective tissue cells  Cardiac myocytes

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15 Alcoholic Cardiomyopathy Peripartum Cardiomyopathy

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23 There are several different injury mechanism associated with cardiac toxicants.  Generation of free redicals  Lipid peroxidation  Impaired membrane integrity  Mitochondrial dysfunction  Sarcoplasmic reticulum dysfunction  Altered calcium homeostasis

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25  Direct and indirect damage to the hematopoietic system may produce hypoxia, hemorrhage, infection and death.  Primary hematotoxicity  Secondary hematotoxicity

26 Ethanol Sideroblastic anemia Benzene Aplastic anemia Vinyl chloride Acquride prophyria NitratesMethemoglobinemia AntimonyNeutropenia ArsineThrombocytopenia Methyl chloride Hemolytic anemia Warfarin Alteration in blood clotting system Alkylating agents Agranulocytopenia


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