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Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer Presented By Junzo Hamanishi.

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Presentation on theme: "Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer Presented By Junzo Hamanishi."— Presentation transcript:

1 Efficacy and safety of anti-PD-1 antibody (Nivolumab: BMS-936558, ONO-4538) in patients with platinum-resistant ovarian cancer Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

2 PD-1/ PD-L1 pathway in suppressing anti-tumor immunity Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

3 Slide 3 Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

4 Nivolumab (ONO4538/BMS936558) Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

5 Study design: Investigator initiated, 2 cohorts Phase II Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

6 Key inclusion criteria Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

7 Study schedule Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

8 Demographics Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

9 Adverse events: Regardless of causality (>=4 patients) Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

10 Slide 10 Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

11 Serious adverse events (Treatment-related) Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

12 Clinical Effect : Best Overall Response Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

13 A Responder with Serous adenoca : Nivolumab 3mg/kg Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

14 A Responder with Clear cell carcinoma : Nivolumab 3mg/kg Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

15 Best overall responses in all patients Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

16 Best overall responses in all patients in 2 cohorts Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

17 Summary Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

18 Conclusions Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

19 Acknowledgements Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

20 Research group Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

21 Slide 21 Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

22 Clinical Effect : Response Duration Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

23 Best overall responses in all patients Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting

24 Slide 24 Presented By Junzo Hamanishi at 2014 ASCO Annual Meeting


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