1. Welcome to Bio 290, Introduction to Genetics!

2. Today’s Agenda: 1. Introduction of Colleagues 2. Introduction to Course, Expectations, and Website 3. Reviewing the Foundations of Genetics (In- Class Assignment 1) 4. Introduction to Single-Gene Inheritance (Ch 2) 5. Poster Project Brainstorm

3. “Big Ideas” in Single-Gene Inheritance: 1. Gene and Chromosome Structure and Packing

4. “Big Ideas” in Single-Gene Inheritance: 2. Representations of Genes and Chromosomes

5. “Big Ideas” in Single-Gene Inheritance: 2. Representations of Genes and Chromosomes

6. “Big Ideas” in Single-Gene Inheritance: 2. Representations of Genes and Chromosomes

7. “Big Ideas” in Single-Gene Inheritance: 3. Mendel’s Contributions Watch for some new terms here! What does it mean to be haplosufficient, or haploinsufficient? What’s a leaky mutation?

8. “Big Ideas” in Single-Gene Inheritance: 4. Chromosome Structure and Function During Meiosis FIGURE: Model of the synaptonemal complex (SC). Lateral elements (light blue rods) of homologous chromosomes align and synapse together via a meshwork of transverse filaments (white lines) and longitudinal filaments (dark blue rods). The longitudinal filaments are collectively referred to as the "central element" of the SC. Ellipsoidal structures called recombination nodules (e.g., gray ellipsoid) are constructed on the central region of the SC. (Image: Mississippi Genome Exploration Lab)

9. “Big Ideas” in Single-Gene Inheritance: 5. Value and Diversity of Model Organisms What advantage might a haploid- dominant organism like yeast, above, provide for a geneticist? What advantages do Drosophila, above, provide for a geneticist? What advantages do mice as a model organism offer a geneticist? Any disadvantages?

10. “Big Ideas” in Single-Gene Inheritance: 6. Sex-Liked Genes Have Unusual Inheritance Patterns What’s unusual about white-eyed fruit flies? Watch for new terms: What does it mean to be hemizygous? What’s a? pseudoautosomal region

11. “Big Ideas” in Single-Gene Inheritance: 7. Pedigree Analysis is a Powerful Way to Represent Inheritance

12. Poster Project Brainstorm: What are the most interesting recent developments in Genetics? What do I find fascinating about the field?

13. Reminders for Next Week 1. Review Paper - Start Reading! (Pre-class assignment on Review Paper due Thursday at 2) 2. Read Chapter 2: Focus on key points we’ve identified today to help you prepare for the Quiz 3. Quiz 2- Posted by Monday at noon, due by Wednesday at noon. 4. Don’t forget to use our fabulous Discussion Room!