1. Tony G.Waldrop Vice Chancellor Research and Economic Development UNC-Chapel Hill and the NIH Roadmap NIH ROADMAP

2. NIH’s Roadmap Vision Est. 2% of total NIH budget Primary funding source: “tax” on NIH institutes Emphasis: Attacking difficult problems Interdisciplinary collaboration Translation to clinic Computation/informatics Allied projects will make Roadmap much larger than its core funding Dr. Elias Zerhouni

3. Themes New Pathways to Discovery Building Blocks, Pathways, and Networks Molecular Libraries and Imaging Structural Biology Bioinformatics and Computational Biology Nanomedicine Research Teams of the Future High-Risk Research Interdisciplinary Research Public Private Partnerships Re-engineering the Clinical Research Enterprise Clinical Research Dorsal root ganglia neurons (Annette Markus)

4. Roadmap Planning at UNC September, 2003: Dr. Zerhouni announces the Roadmap January, 2004: 12-member Carolina Roadmap Task Force is convened March, 2004: Task Force report recommends: –Create a campus-wide organization for Roadmap projects –Demonstrate administrative support –Appoint a Roadmap chair –Provide staff and resources

5. UNC’s Response NIH Roadmap Executive Committee Chair: Rudy Juliano, Professor of Pharmacology Executive Committee members: –Kim Brouwer, Chair Pharmacotherapy, Pharmacy –Barbara Entwisle, Director, Carolina Population Center and Professor of Sociology –Michael Fried, Professor of Medicine and Director, Hepatology Division of Gastroenterology and Hepatology –Daniel Reed, Vice Chancellor for Information Technology and Director, Institute for Renaissance Computing –Rich Superfine, Professor of Physics –David Savitz, Chair of Epidemiology

6. Campus Support Roadmap Committee will steer efforts to –Build research teams and partnerships at UNC –Liaise with NIH on Roadmap –Highlight interdisciplinary research (‘workshops’) –Facilitate development of proposals –A new staff position (Karen Stone) Seed funding from VC for proposal development Additional support from –Offices within Research and Economic Development –College of Arts and Sciences –Schools of Medicine, Dentistry, Public Health Freeze-dried, rehydrated platelets in a canine carotid artery. (Tom Fishcher)

7. The first round of Roadmap P20 RFAs yields multiple UNC proposals REC meets with multiple Departments/Centers VC’s “Workshops In Interdisciplinary Research” Emerging Initiatives Metabolomics— Steve Zeisel, others Stem Cells & Transplantation—Jon Serody, others Peridontal Disease—Steve Offenbacher, others Biomedical Research Imaging Center—Etta Pisano, others Pathways & Networks—Klaus Hahn others Child abuse & physiological changes- Jonathan Kotch, others Other projects?? Action Fluorescent video microscopy images of cell mitosis (Ted Salmon)

8. SUCCESSES Roadmap Planning Grant or other Awards PIThemeDepartment/Center 1.B. PopkinObesityPopulation Center 2.R. RindfussLand Use & HealthPopulation Center 3.B. SartorImaging Inflammation Medicine 4.D. Reed/Exploratory GeneticsComputer Sci/ T. MagnusonGenetics 5.G. JohnsonNanomedicinePharmacology 6.H. GuessPatient OutcomesPublic Health

9. WHAT NEXT? 1.LOOKING FOR A FEW GOOD MEN/WOMEN 2. DARE TO DREAM BIG DREAMS

10. Help the Roadmap at UNC 1.Consider leading a Roadmap or Roadmap-Like proposal. Let us know about it!! 2. Help us to ‘penetrate’ the NIH. Are you on NIH Council? Study Section? Advisory Group? Let us know about it!!