1. The Endocrine System Chapter 36

2. Objectives – What you will need to know from this section Define the term: hormone. Outline the Endocrine System. Compare action, distinguishing between exocrine & endocrine glands. State the location of the principal glands in the human. Outline for each gland, one hormone & its function. Explain 1 Hormone giving a description of its deficiency symptoms, excess symptoms & corrective measures Name 2 examples of hormone supplements & their use.

3. Two systems are needed to co-ordinate body responses 1.Endocrine (hormone) system 2.Nervous System

4. The endocrine system is a group of specialised tissues (glands) that produce chemicals called hormones, many of which are proteins. Thyroid Pancreas Adrenal Pituitary O The ability to detect change and to respond is called sensitivity. Response is a form of defence that allows organisms to survive.

5. Definitions Glands – Structures that secrete substances e.g. thyroid gland Two types: 1.Exocrine glands – They release their products into ducts or tubes e.g. salivary glands 2. Endocrine glands – This is a ductless gland that produces hormones which are released directly into the bloodstream e.g. pancreas The endocrine glands interact with the nervous system to provide the communication, co-ordination and control within the body.

6. Hormones are chemical ‘messengers’, produced in specialised glands, and transported in the blood to a particular area (the target organ), where they have their effect. E.g. insulin Hormones are mainly made of PROTEIN. Some hormones are steroid based (made of lipid) e.g. male hormones Even though hormones are carried to all parts of the body in the blood stream they only affect specific areas called TARGET TISSUES or TARGET ORGANS

7.  The action of hormones is slower and more general than nerve action and they control mainly long-term changes such as growth, metabolism and sexual maturity.  On passing through the liver, the hormones are broken down and excreted by the kidneys.  The nervous system relies on electrical signals, carried by specialised cells, and is involved in fast responses.

8. FeatureNervous SystemEndocrine System Speed of response Method used to carry messages Speed of messages Duration of response Location affected Comparison of Nervous & Endocrine System

9. Comparison of the endocrine and nervous systems - 1 Target organReceived by BloodCarried by GlandCells involved Cells throughout the body Message sent to Chemical (Hormone) Message Endocrine

10. Comparison of the endocrine and nervous systems - 1 EndocrineNervous Cells involvedGlandSense receptor MessageChemical (Hormone) Electrical(Impulse) Carried byBloodNerve cell Message sent toCells throughout the body A specific cell or tissue Received byTarget organEffector (muscle or gland)

11. long-lasting (hours) Duration Can be widespreadEffects Usually slowSpeed of transmission Endocrine Comparison of the endocrine and nervous systems -- 2

12. EndocrineNervous Speed of transmission Usually slowRapid EffectsCan be widespreadLocalised usually Durationlong-lasting (hours) Usually brief (seconds) Comparison of the endocrine and nervous systems -- 2

13. LEARNING CHECK What is sensitivity? What are endocrine glands? What are exocrine glands? What is the nervous system? Give the main differences between the nervous and endocrine systems.

14. ENDOCRINE GLANDS

15. For each of the principal endocrine glands you must know the location name and function of one hormone Endocrine Gland LocationName of hormoneFunction of hormone Pituitary Gland Hypothalamus Pineal Gland Thyroid Gland Parathyroid Gland Thymus Adrenals

16.  Most hormone activity is controlled directly or indirectly by the hypothalamus and pituitary gland.  The brain region keeps a check on internal organs and activities, such as the level of carbon dioxide or water in the blood.

17. 1. Pituitary Gland The pituitary is often called the ‘master gland’, as many of its hormones trigger other glands to release theirs.

18. The pituitary gland is located in the brain. It releases ADH to stimulate water reabsorption in the kidneys, TSH which stimulates the thyroid gland to release thyroxine, and FSH which controls the functions of the reproductive organs. It also produces growth hormone which causes elongation of the bones.

19. 2. Hypothalamus Located in the brain Links the endocrine & nervous system Hypothalamus releases anti-diuretic hormone (ADH) which is then stored in the pituitary gland. ADH causes water to be reabsorbed in the kidneys. 3. Pineal Gland Located in the brain Produces hormone melatonin which is involved in biological rhythms e.g. sleep patterns

20. 4. Thyroid Gland The thyroid gland, in the neck, produces thyroxine, which stimulates metabolism. 5. Parathyroid Gland The parathyroid produces parathyroid hormone, which increases blood calcium levels.

21. 6. Thymus Gland Located behind the breast bone in the upper chest. Produces hormone thymosin which causes lymphocytes (white blood cells) to mature and become active. 7. Adrenal Glands Located on top of the kidneys in the lower back. They produce hormone adrenaline which helps the bodycope with stress and is called the fight or flight hormone.

22. 8. Pancreas The pancreas is both an endocrine and exocrine gland The Islets of Langerhans produce insulin, while the rest produces enzymes for digestion. Insulin stimulates cells to absorb glucose from the blood, and store it as glycogen.

23. 9. Ovary & Testes The ovary produces oestrogen and progesterone to prepare the female for pregnancy. The testes produce testosterone which triggers sperm production and growth in the male.

25. Quiz Name the main endocrine gland in the body? Name one hormone produced by each gland? Give one function for each hormone? Why is the pituitary often called the “master gland”? Where would you find the Islets of Langerhans?

26. Endocrine glands can sometimes malfunction  Low levels of thyroxine reduce the rate of metabolism.  Taking the hormone in tablet form once a day can solve the problem – hormone supplement THYROID gland:  Excess thyroxine can greatly increase metabolic rate.  Treatment is often by removal of part of the gland. DISORDERS of the Endocrine System

27.  In oral contraceptives, oestrogen and progesterone are taken to prevent pregnancy – hormone supplement PANCREAS gland:  In some people, the pancreas cannot produce insulin, which results in diabetes mellitus.  Glucose cannot get into cells, which disrupts metabolism.  Regular daily injections of insulin are required – hormone supplement. OVARIES gland:

28. Quiz Name some disorders of the endocrine system? For each one, give the symptoms and a possible treatment for the disorder? What are hormone supplements?