1. 0.25 0.50 0.75 1.00 1.25 1.50 1.75 Subgroup Vitamin C Active Group Placebo Group P value for Interaction Age 45-54 yr 141 171 (No. of cases) 55-64 yr 158 181  65 yr 121 123 <25.0 32 42 25.0-29.9 98 101  30.0 288 331 BMI High, >1000kcal/wk 116 123 Low,  1000kcal/wk 302 351 Physical Activity 0.11 0.88 0.29 Current 59 87 Past 198 188 Never 163 200 Cigarette Smoking 0.05 Never/rarely 250 291  1 drink/mon 170 184 Alcohol Intake 0.26 Premenopausal 28 48 Uncertain 69 88 Postmenopausal, current HT use 155 175 Menopausal status and HT use 0.14 Postmenopausal, no HT use 162 157 Yes 204 245 No 194 209 Family History of diabetes 0.63 Yes 349 405 No 71 70 History of Hypertension 0.17 Yes 349 367 No 71 108 History of Hypercholesterolemia 0.01 Tertile 1 (9.1-130) 135 147 Tertile 2 (130-216) 127 150 Dietary vitamin C intake (mg/d) 0.99 Tertile 3 (216-280) 129 147 Relative Risk for Type 2 Diabetes A Supplemental Figure 1.

2. 0.50 1.00 1.50 2.00 2.50 Relative Risk for Type 2 Diabetes Subgroup Vitamin E Active Group Placebo Group P value for Interaction Age 45-54 yr 159 153 (No. of cases) 55-64 yr 178 161  65 yr 137 107 <25.0 44 30 25.0-29.9 103 96  30.0 326 293 BMI High, >1000kcal/wk 121 118 Low,  1000kcal/wk 352 301 Physical Activity 0.30 0.37 0.40 Current 178 168 Past 199 187 Never 197 166 Cigarette Smoking 0.57 Never/rarely 279 262  1 drink/mon 195 159 Alcohol Intake 0.57 Premenopausal 36 40 Uncertain 80 77 Postmenopausal, current HT use 173 157 Menopausal status and HT use 0.27 Postmenopausal, no HT use 179 140 Yes 240 209 No 212 191 Family History of diabetes 0.30 Yes 394 360 No 80 61 History of Hypertension 0.58 Yes 377 339 No 97 82 History of Hypercholesterolemia 0.61 0.21 Supplemental Figure 1. Tertile 1 (1.82-9.75) 151 121 Tertile 2 (9.76-43.7) 153 147 Dietary vitamin E intake (IU/d) Tertile 3 (43.8-899) 132 131 B

3. 0.50 1.00 1.50 2.00 2.50 Subgroup  -Carotene Active Group Placebo Group P value for Interaction Age 45-54 yr 159 153 (No. of cases) 55-64 yr 178 161  65 yr 137 107 <25.0 44 30 25.0-29.9 103 96  30.0 326 293 BMI High, >1000kcal/wk 121 118 Low,  1000kcal/wk 352 301 Physical Activity 0.30 0.37 0.40 Current 178 168 Past 199 187 Never 197 166 Cigarette Smoking 0.57 Never/rarely 279 262  1 drink/mon 195 159 Alcohol Intake 0.57 Premenopausal 36 40 Uncertain 80 77 Postmenopausal, current HT use 173 157 Menopausal status and HT use 0.27 Postmenopausal, no HT use 179 140 Yes 240 209 No 212 191 Family History of diabetes 0.30 Yes 394 360 No 80 61 History of Hypertension 0.58 Yes 377 339 No 97 82 History of Hypercholesterolemia 0.61 0.21 Tertile 1 (1.82-9.75) 151 121 Tertile 2 (9.76-43.7) 153 147 Dietary total carotene intake (mg/d) Tertile 3 (43.8-899) 132 131 Relative Risk for Type 2 Diabetes Supplemental Figure 1. C