1. Automated Syringe Dosing: The EasyMeasure Syringe Hanson, E.E., Weisshaar, C.L., Wentland, A.L. Biomedical Engineering University of Wisconsin – Madison Advisor: Willis J. Tompkins, Ph.D.

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3. Background/Motivation Many diabetes patients use syringes on a daily basis to inject insulin For diabetes patients with vision problems and neuromuscular disorders  It becomes difficult to read the volume of fluid on the syringe set the syringe’s plunger to the correct dosage Draw/inject the plunger at a steady rate (preventing air bubbles)

4. Current products Insulin pumps (Minimed) [1]  Costly (~$5,000)  Must be worn constantly and programmed Autoject2 ® -Owen Mumford [2]  Assists in injecting, not dosing Nordisk Novopen ® [3]  Requires some dexterity to set the dosage correctly  Uses only one type of insulin

5. Motor Keypad Digital Display Syringe

6. Progress Received new motor Soldered circuit for new motor Outlined microprocessor program with error handling Began to program the digital display

7. New, Smaller Motor

8. Microcontroller: Programming Perfect User User inserts syringe Secures syringe Presses ‘on’ button Presses clear  resets device Enters desired amount (0-100 units) Presses enter, # displayed Inserts syringe into medication bottle Presses ‘Fill’, syringe draws up liquid Inserts needle into tissue Presses ‘Inject’ Removes syringe from tissue Discards disposable syringe, device shuts off after 1 min

9. Microcontroller: Programming User Error 1 User inserts syringe Secures syringe Presses ‘on’ button Presses clear  resets device Enters desired amount (0-100 units) Presses enter, # displayed Inserts syringe into medication bottle Presses ‘Fill’, syringe draws up liquid Inserts needle into tissue Presses ‘Inject’ Removes syringe from tissue Discards disposable syringe, device shuts off after 1 min User has entered incorrect amount

10. Microcontroller: Programming User Error 2 User inserts syringe Secures syringe Presses ‘on’ button Presses clear  resets device Enters desired amount (0-100 units) Presses enter, # displayed Inserts syringe into medication bottle Presses ‘Fill’, syringe draws up liquid Inserts needle into tissue Presses ‘Inject’ Removes syringe from tissue Discards disposable syringe, device shuts off after 1 min User realizes error; incorrect amount User presses clear/stop Syringe displays current volume User decides course of action Presses inject; leftover fluid goes into insulin bottle Injects a little more fluid

11. Potential Device Errors Device fails to deliver correct amount  User will be able to view syringe as it delivers medication  Device displays current volume as plunger moves  ‘Error’ message & beep if syringe is not inserted properly or fails to draw/inject all fluid

12. Cost Comparison Cost: Insurance Companies Cost: Patient Pump$5,000$0 Novopen ® (6 pens)$80+~$13 The EasyMeasure Syringe $100-300 Potentially $0 [1] [4] [5]

13. Market of Personal Care Products “The development of in-home medical technologies, substantial cost savings, and patients’ preference for care in the home have helped make this once small segment of the industry into one of the fastest growing in the U.S. economy.”  Career Guide to Industries, Bureau of Labor Statistics [6]

14. Market: >65 years In 2002, 12.4% of population was >65 [7]  12.4% of the population accounts for 40% of the annual healthcare costs [7] By 2020, this age group is expected to climb to 17% of the population [8] Diabetes and obesity on the rise [9] [10]

15. References [1] Medtronic. MiniMed. http://www.minimed.com/. 2004. [2] Owen Mumford. Autoject 2: Self injection made simpler…http://www.owenmumford.com /autoject2.html. 2004. [3] Novo Nordisk. NovoPen® 3 – An unsurpassed range. http://www.novonordisk.com/diabete s/public/insulinpens/novopen3/default.asp. 2004. [4] Midbon, Missy. Diabetes patient interview. 9/10/04. [5] Haist, Doug. Diabetes and Parkinson’s disease patient interview. 10/06/04. [6] Bureau of Labor Statistics. Industry Employment. Winter, 2000. [7] Healthcare Products & Supplies Industry Survey: Industry Trends. Standard & Poor’s Industry Surveys. Sept. 23, 2004. [8] US Census Bureau. Percent Distribution of the Population by Age: 1990 to 2050. http://www.census.gov/prod/1/pop/p25-1130/p251130b.pdf. 2005. [9] World Health Organization. Obesity and Overweight. http://www.who.int/hpr/NPH/docs/ gs_obesity.pdf. 2005. [10] International Union of Nutritional Sciences. http://www.iuns.org/features/obesity/tabfig.htm. 2005.