1. © 2013 Pearson Education, Inc. Chapter 18: Practical Applications of Immunology $100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 VaccinationVaccines Diagnostic Tests ELISA Therapeutic Immunity FINAL ROUND

2. © 2013 Pearson Education, Inc. Topic 1: Vaccination $100 Question The term vaccination was coined to honor the work of a. Alexander Fleming. b. Louis Pasteur. c. Edward Jenner. d. Robert Koch. ANSWER BACK TO GAME

3. © 2013 Pearson Education, Inc. Topic 1: Vaccination $100 Answer The term vaccination was coined to honor the work of a. Alexander Fleming. b. Louis Pasteur. c. Edward Jenner. d. Robert Koch. BACK TO GAME

4. © 2013 Pearson Education, Inc. Topic 1: Vaccination $200 Question Vaccination is frequently the ONLY feasible method of controlling diseases caused by a. fungi. b. bacteria. c. viruses. d. protozoa. BACK TO GAME ANSWER

5. © 2013 Pearson Education, Inc. Topic 1: Vaccination $200 Answer Vaccination is frequently the ONLY feasible method of controlling diseases caused by a. fungi. b. bacteria. c. viruses. d. protozoa. BACK TO GAME

6. © 2013 Pearson Education, Inc. Topic 1: Vaccination $300 Question When most of the population is immune, the population is said to possess _____ immunity. a. herd b. innate c. population d. natural BACK TO GAME ANSWER

7. © 2013 Pearson Education, Inc. Topic 1: Vaccination $300 Answer When most of the population is immune, the population is said to possess _____ immunity. a. herd b. innate c. population d. natural BACK TO GAME

8. © 2013 Pearson Education, Inc. Topic 1: Vaccination $400 Question Which of the following diseases can be controlled by behavioral and environmental methods? a. cholera b. measles c. rubella d. chickenpox BACK TO GAME ANSWER

9. © 2013 Pearson Education, Inc. Topic 1: Vaccination $400 Answer BACK TO GAME Which of the following diseases can be controlled by behavioral and environmental methods? a. cholera b. measles c. rubella d. chickenpox

10. © 2013 Pearson Education, Inc. Topic 1: Vaccination $500 Question Which vaccine is administered as two doses at least 6 months apart in children? a. MMR vaccine b. polio vaccine c. hepatitis A vaccine d. Hib vaccine BACK TO GAME ANSWER

11. © 2013 Pearson Education, Inc. Topic 1: Vaccination $500 Answer BACK TO GAME Which vaccine is administered as two doses at least 6 months apart in children? a. MMR vaccine b. polio vaccine c. hepatitis A vaccine d. Hib vaccine

12. © 2013 Pearson Education, Inc. Topic 2: Vaccines $100 Question Which vaccines more closely mimic an actual infection? a. attenuated whole-agent b. inactivated whole-agent c. subunit d. conjugated BACK TO GAME ANSWER

13. © 2013 Pearson Education, Inc. Topic 2: Vaccines $100 Answer Which vaccines more closely mimic an actual infection? a. attenuated whole-agent b. inactivated whole-agent c. subunit d. conjugated BACK TO GAME

14. © 2013 Pearson Education, Inc. Topic 2: Vaccines $200 Question The Salk polio vaccine is an example of a(n) a. inactivated whole-agent vaccine. b. toxoid. c. attenuated whole-agent vaccine. d. acellular vaccine. BACK TO GAME ANSWER

15. © 2013 Pearson Education, Inc. Topic 2: Vaccines $200 Answer The Salk polio vaccine is an example of a(n) a. inactivated whole-agent vaccine. b. toxoid. c. attenuated whole-agent vaccine. d. acellular vaccine. BACK TO GAME

16. © 2013 Pearson Education, Inc. Topic 2: Vaccines $300 Question Which of the following vaccines uses ONLY the antigenic fragments of a microorganism that best stimulate an immune response? a. nucleic acid vaccines b. conjugated vaccines c. subunit vaccines d. inactivated killed vaccines BACK TO GAME ANSWER

17. © 2013 Pearson Education, Inc. Topic 2: Vaccines $300 Answer Which of the following vaccines uses ONLY the antigenic fragments of a microorganism that best stimulate an immune response? a. nucleic acid vaccines b. conjugated vaccines c. subunit vaccines d. inactivated killed vaccines BACK TO GAME

18. © 2013 Pearson Education, Inc. Topic 2: Vaccines $400 Question The development of cell culture techniques was very important in the development of vaccines for diseases caused by a. protozoa. b. fungi. c. bacteria. d. viruses. ANSWER BACK TO GAME

19. © 2013 Pearson Education, Inc. Topic 2: Vaccines $400 Answer The development of cell culture techniques was very important in the development of vaccines for diseases caused by a. protozoa. b. fungi. c. bacteria. d. viruses. BACK TO GAME

20. © 2013 Pearson Education, Inc. Topic 2: Vaccines $500 Question Which of the following has been added to vaccines to increase the effectiveness of antigens? a. adjuvants b. formalin c. phenol d. polysaccharides BACK TO GAME ANSWER

21. © 2013 Pearson Education, Inc. Topic 2: Vaccines $500 Answer Which of the following has been added to vaccines to increase the effectiveness of antigens? a. adjuvants b. formalin c. phenol d. polysaccharides BACK TO GAME

22. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $100 Question Antibody molecules that are produced by a single hybridoma clone are called a. human antibodies. b. monoclonal antibodies. c. hybrid cells. d. identical antibodies. BACK TO GAME ANSWER

23. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $100 Answer Antibody molecules that are produced by a single hybridoma clone are called a. human antibodies. b. monoclonal antibodies. c. hybrid cells. d. identical antibodies. BACK TO GAME

24. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $200 Question Which test involves the reaction of soluble antigens with IgG or IgM antibodies to form lattices? a. precipitin ring test b. direct agglutination test c. indirect agglutination test d. viral hemagglutination inhibition test BACK TO GAME ANSWER

25. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $200 Answer Which test involves the reaction of soluble antigens with IgG or IgM antibodies to form lattices? a. precipitin ring test b. direct agglutination test c. indirect agglutination test d. viral hemagglutination inhibition test BACK TO GAME

26. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $300 Question An antigen–antibody reaction in which specific antibodies block the harmful effects of a bacterial exotoxin or a virus is a(n) _____ reaction. a. neutralization b. precipitation c. direct agglutination d. indirect agglutination BACK TO GAME ANSWER

27. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $300 Answer An antigen–antibody reaction in which specific antibodies block the harmful effects of a bacterial exotoxin or a virus is a(n) _____ reaction. a. neutralization b. precipitation c. direct agglutination d. indirect agglutination BACK TO GAME

28. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $400 Question Immunoelectrophoresis is an essential part of a. the Western blot test. b. seroconversion. c. the precipitin ring test. d. the direct agglutination test. BACK TO GAME ANSWER

29. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $400 Answer BACK TO GAME Immunoelectrophoresis is an essential part of a. the Western blot test. b. seroconversion. c. the precipitin ring test. d. the direct agglutination test.

30. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $500 Question What tests are commonly used for the rapid detection of serum antibodies against many bacterial and viral diseases? a. direct agglutination b. immunodiffusion c. latex agglutination d. viral hemagglutination inhibition BACK TO GAME ANSWER

31. © 2013 Pearson Education, Inc. Topic 3: Diagnostic Tests $500 Answer What tests are commonly used for the rapid detection of serum antibodies against many bacterial and viral diseases? a. direct agglutination b. immunodiffusion c. latex agglutination d. viral hemagglutination inhibition BACK TO GAME

32. © 2013 Pearson Education, Inc. Topic 4: ELISA $100 Question The ELISA procedures are very popular because they a. are inexpensive. b. are easy to perform. c. require little interpretive skill to read. d. test for many diseases. BACK TO GAME ANSWER

33. © 2013 Pearson Education, Inc. Topic 4: ELISA $100 Answer The ELISA procedures are very popular because they a. are inexpensive. b. are easy to perform. c. require little interpretive skill to read. d. test for many diseases. BACK TO GAME

34. © 2013 Pearson Education, Inc. Topic 4: ELISA $200 Question The indirect ELISA test differs from the direct ELISA test in that it detects a. antigens. b. antibodies. c. enzymes. d. toxins. ANSWER BACK TO GAME

35. © 2013 Pearson Education, Inc. Topic 4: ELISA $200 Answer BACK TO GAME The indirect ELISA test differs from the direct ELISA test in that it detects a. antigens. b. antibodies. c. enzymes. d. toxins.

36. © 2013 Pearson Education, Inc. Topic 4: ELISA $300 Question What is adsorbed to the well on the microtiter plate in a direct ELISA? a. antibodies b. cells c. antigens d. enzymes BACK TO GAME ANSWER

37. © 2013 Pearson Education, Inc. Topic 4: ELISA $300 Answer What is adsorbed to the well on the microtiter plate in a direct ELISA? a. antibodies b. cells c. antigens d. enzymes BACK TO GAME

38. © 2013 Pearson Education, Inc. Topic 4: ELISA $400 Question In the indirect ELISA test, the microtiter well contains a(n) a. antibody b. enzyme. c. antigen. d. substrate. BACK TO GAME ANSWER

39. © 2013 Pearson Education, Inc. Topic 4: ELISA $400 Answer BACK TO GAME In the indirect ELISA test, the microtiter well contains a(n) a. antibody b. enzyme. c. antigen. d. substrate.

40. © 2013 Pearson Education, Inc. Topic 4: ELISA $500 Question In a direct ELISA, which of the following does the patient provide? a. antigen b. antibodies c. substrate d. enzymes BACK TO GAME ANSWER

41. © 2013 Pearson Education, Inc. Topic 4: ELISA $500 Answer BACK TO GAME In a direct ELISA, which of the following does the patient provide? a. antigen b. antibodies c. substrate d. enzymes

42. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $100 Question Diagnostic immunology was revolutionized by the introduction of a. Western blotting. b. the ELISA test. c. complement fixation. d. monoclonal antibodies. BACK TO GAME ANSWER

43. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $100 Answer BACK TO GAME Diagnostic immunology was revolutionized by the introduction of a. Western blotting. b. the ELISA test. c. complement fixation. d. monoclonal antibodies.

44. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $200 Question Which of the following tests has declined in use? a. complement-fixation tests b. precipitin ring test c. immunoelectrophoresis d. fluorescent-antibody tests BACK TO GAME ANSWER

45. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $200 Answer Which of the following tests has declined in use? a. complement-fixation tests b. precipitin ring test c. immunoelectrophoresis d. fluorescent-antibody tests BACK TO GAME

46. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $300 Question Which of the following is a therapeutic application of monoclonal antibodies? a. identifying breast cancer b. treating Hodgkin’s lymphoma c. testing for drugs in urine d. diagnosing HIV infection BACK TO GAME ANSWER

47. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $300 Answer BACK TO GAME Which of the following is a therapeutic application of monoclonal antibodies? a. identifying breast cancer b. treating Hodgkin’s lymphoma c. testing for drugs in urine d. diagnosing HIV infection

48. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $400 Question Which of the following is a nonimmunological test? a. ELISA b. PCR c. Western blot d. FACS BACK TO GAME ANSWER

49. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $400 Answer Which of the following is a nonimmunological test? a. ELISA b. PCR c. Western blot d. FACS BACK TO GAME

50. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $500 Question Most newer tests a. are less sensitive. b. require more judgment to read. c. require less highly trained personnel. d. are more time consuming. BACK TO GAME ANSWER

51. © 2013 Pearson Education, Inc. Topic 5: Therapeutic Immunity $500 Answer Most newer tests a. are less sensitive. b. require more judgment to read. c. require less highly trained personnel. d. are more time consuming. BACK TO GAME

52. © 2013 Pearson Education, Inc. FINAL ROUND Question A patient’s blood did NOT have any antibody titer before an illness but has a significant titer while the disease is progressing. This phenomenon, which occurs in HIV infections, is called a. variolation. b. attenuation. c. seroconversion. d. agglutination. BACK TO GAME ANSWER

53. © 2013 Pearson Education, Inc. FINAL ROUND Answer A patient’s blood did NOT have any antibody titer before an illness but has a significant titer while the disease is progressing. This phenomenon, which occurs in HIV infections, is called a. variolation. b. attenuation. c. seroconversion. d. agglutination. BACK TO GAME