1. Neglected tropical diseases (diseases of poverty) Warwick Grant Department of Animal, Plant and Soil Sciences

2. What are neglected tropical diseases? These are primarily diseases of poverty They either do not occur at all in developed countries or are rare and of minor importance But they affect tens to hundreds of millions in developing countries, especially in sub- Saharan Africa where the poorest of the poor are concentrated

3. Parasitic diseases are very common more that two thirds of the world population carry one more more species of parasite the most common are gastrointestinal helminths... or worms in plain English roundworms such as Ascaris, hookworms and Trichuris and flat worms such as Schistosoma. they rarely kill outright but they cause great morbidity (morbidity vs. mortality... who knows the difference?)

4. What are the diseases? They are listed at: http://apps.who.int/tdr/svc/diseases This is the website of the branch of the World Health Organisation (WHO) that has special responsibility for these diseases... Tropical Disease Research or TDR There are other links to more Non- Governmental Organisations, or NGO’s: just Google “neglected tropical diseases”

5. River blindness, or onchocerciasis spread by blackflies... called river blindness because the flies must be near a river to breed symptoms are slow to develop but the infection is essentially incurable the symptoms are caused by the baby worms in the skin....

6. Carter Center oncho promo Oncho animation More information about APOC http://www.ploscollections.org/article/browse/i ssue/info%3Adoi%2F10.1371%2Fissue.pcol.v08.i 11

7. Where?

8. The life cycle

9. http://apps.who.int/tdr/resources/animations /onchocerciasis-life-cycle.swf http://apps.who.int/tdr/resources/animations /onchocerciasis-life-cycle.swf

10. Blindness estimates vary, but there are probably around 400,000 people who are blind or sight impaired as a result of infection there are possible 15 million total infections and an “at risk” population in the hundreds of millions no-one dies as a direct result of onchocerciasis but the infection may shorten life expectancy by 15+ years

11. Severe dermatitis

12. DALYS the WHO love their acronyms and this is a good one Daily Adjusted Life YearS this is a measure of how much quality of life is lost as well as quantity of life for most of the neglected diseases of poverty, the DALYS are the important measure

13. Lifelong infection, suffering and disability onchocerciasis causes: – blindness in severe cases – disfigurement of the skin... thickening, scarring, depigmentation – intense itchiness, leading to scratching lesions and secondary infections – disfiguring nodules where the adult worms live – immunological impairment, and disfigurement of the axial and inguinal lymph glands – shortening of life expectancy

14. So what? The TDR (remember that is the branch of the World Health Organisation with special responsibility for these diseases) The TDR has a total budget of $70 million, for ALL of its activities Individual developed countries spend much, much more than this on diseases that cause a tiny fraction of the suffering

15. In Australia there is some funding (<$10M) for malaria research, largely because it is a “local” problem there is a tiny amount (<$1M) for research on one or two “worm” diseases, but only those that occur close to Australia (eg. in Papua, or in S.E. Asia where tourists go) there is nothing spent on oncho, or many other similarly serious diseases of poverty

16. The question? in philosophy, there is a school of thought that has been around for a long time called “utilitarianism” utilitarians are do-gooders who think we should try to do things that maximise the good in the society... the ethically right thing to do is the thing that brings most benefit to most people this usually means spending what resources are available on measures that help most people

17. What should we do? the Australian National Health and Medical Research Council has as one of their most important funding criteria that research must be focused on Australian health issues this all but rules out funding for the most important diseases in the world unless you can find an Australian angle most other developed countries are the same and the tiny budgets of our government international aid agencies rarely fund disease research. This is especially true of the current gov’t, who see aid as a tool for “international diplomacy” rather than a way to share our wealth with those who are most in need. Is this ethical?

18. Want to know more? even though we officially never recommend Wiki, I suggest: http://en.wikipedia.org/wiki/Onchocerciasis or for a more serious view: http://www.cdc.gov/parasites/onchocerciasis/ and http://apps.who.int/tdr/svc/diseases/helminths or just Google “onchocerciasis”

19. The Life You Can Save http://www.thelifeyoucansave.com/ information about the poorest of the poor, and what you can do about it.... founded by the “utilitarian” Melbourne philosopher Peter Singer... read the book with the same title. And this organisation he helped to found https://www.givingwhatwecan.org http://www.givewell.org/

20. How can you contact me? I am in the Department of Animal, Plant and Soil Sciences My office over in the Agribio building. There are plenty of meeting rooms over there but you have to make an appointment. my email is w.grant@latrobe.edu.auw.grant@latrobe.edu.au your best bet is to email me first to make a time and then come and seem me I have a lot of teaching commitments at the moment but will make time to talk with you if you are interested to follow up.